DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20213778

Prognostic evaluation in head and neck cancer patients: a clinicoimaging tertiary care center study

N. Kavya Keerthika, D. Sri Veda, M. P. V. Prabhat, G. Sarat, Gunmeet Maini

Abstract


Background: The occurrence of the head and neck cancers (HNC) is increasing day by day. These have been associated with multiple etiological factors, and early diagnosis has a prime role in the patient's prognosis and overall survival. Prognostic evaluation in head and neck cancer patients utilizing clinical incidence and imaging outcomes.

Methods: The study sample included 217 confirmed HNC patients’ data obtained from the tertiary cancer care centre were analysed to assess the prognosis and be subjected to statistical analysis.

Results: Out of all HNC, cancer pertaining to the lip and oral cavity was the most common variety with 65.89% and most of the HNC occurred in men of about 97%, suggesting a strong association with adverse oral habits.

Conclusions: We conclude that the current scenario of HNC’s progression and treatment modalities in Andhra Pradesh were in comparison to the World Health Organization (WHO) data suggests an increase in the awareness of the etiological factors and the disease progression. Though various advanced imaging and treatment modalities are available, the patients' prognosis is untethered due to low socio-economic status in this region.


Keywords


Etiological factors, Head and neck cancer, PET, Prognosis, Tertiary care, Treatment modalities

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References


Locally advanced squamous carcinoma of the head and neck. Union for International Cancer Control. 2014 Review of Cancer Medicines on the WHO List of Essential Medicines. 2014.

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90.

Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132(5):1133-45.

Poddar A, Aranha RR, K Muthukaliannan G, Nachimuthu R, Jayaraj R. Head and neck cancer risk factors in India: protocol for systematic review and meta-analysis. BMJ Open. 2018;8(8):e020014.

Kallalli BN, Rawson K, Kumari V, Patil S, Singh A, Sulaga S. Comparison between clinical examination, ultrasonography, and computed tomography in assessment of cervical lymph node metastasis in oral squamous cell carcinoma. J Indian Acad Oral Med Radiol. 2016;28(4):364-9.

Quinlan-Davidson SR, Mohamed ASR, Myers JN, Gunn GB, Johnson FM, Skinner H, et al. Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy. Oral Oncol. 2017;72:90-7.

GLOBOCAN 2012 (IARC). Section of Cancer Surveillance. Available at: http://globocan.iarc.fr /Pages/fact_sheets_population.aspx. Accessed on 23 June 2016.

Cancer statistics. National Cancer Institute. 2020. Available at: http://nciindia.aiims.edu/en/cancer-statistics. Accessed on 23 June 2016.

Dhull AK, Atri R, Dhankhar R, Chauhan AK, Kaushal V. Major Risk Factors in Head and Neck Cancer: A Retrospective Analysis of 12-Year Experiences. World J Oncol. 2018;9(3):80-4.

Vigneswaran N, Williams MD. Epidemiologic trends in head and neck cancer and aids in diagnosis. Oral Maxillofac Surg Clin North Am. 2014;26(2):123-41.

Shaw R, Beasley N. Aetiology and risk factors for head and neck cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):9-12.

Gilyoma JM, Rambau PF, Masalu N, Kayange NM, Chalya PL. Head and neck cancers: a clinico-pathological profile and management challenges in a resource-limited setting. BMC Res Notes. 2015;8:772.

Bhattacharjee A, Chakraborty A, Purkaystha P. Prevalence of head and neck cancers in the north east-An institutional study. Indian J Otolaryngol Head Neck Surg. 2006;58(1):15-9.

Schlumpf MF, Haerle S. The current role of imaging in head and neck cancer: a clinician's perspective. Swiss Med Wkly. 2014;144:14015.

Lewis-Jones H, Colley S, Gibson D. Imaging in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):28-31.

Woolgar JA, Triantafyllou A. Prognostic biological features in neck dissection specimens. Eur Arch Otorhinolaryngol. 2013;270:1581-92.

Alam MS, Siddiqui SA, Perween R. Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor. J Cancer Res Ther. 2017;13(3):430-5.

Koch WM, Ridge JA, Forastiere A, Manola J. Comparison of clinical and pathological staging in head and neck squamous cell carcinoma: results from Intergroup Study ECOG 4393/RTOG 9614. Arch Otolaryngol Head Neck Surg. 2009;135(9):851-8.

Mehta N, Sharma R, Madhok R, Agrawal T, Sharma V. A Clinical, Radiological, and Histopathological Correlation of Neck Nodes in Patients Undergoing Neck Dissection. Int J Appl Basic Med Res. 2018;8(1):9-13.

Martino ED. A comparsion of modern imaging modalities (PET, CT, Color coded USG) with pandescopic and histopathological findings. Arch- Otolaryngol Head and Neck Surg. 2000;126.

Lo Nigro C, Denaro N, Merlotti A, Merlano M. Head and neck cancer: improving outcomes with a multidisciplinary approach. Cancer Manag Res. 2017;9:363-71.

Adeyi A, Olugbenga S. The challenges of managing malignant head and neck tumors in a tropical tertiary health center in Nigeria. Pan Afr Med J. 2011;10:31.

Chrong N, Vokes E. Expanding role of the medical oncologist in the management of head/neck cancer. CA Cancer J C/M. 2008;58:32-53.

Gilyoma JM, Rambau PF, Masalu N, Kayange NM, Chalya PL. Head and neck cancers: a clinico-pathological profile and management challenges in a resource-limited setting. BMC Res Notes. 2015;8:772.

Paleri V, Urbano TG, Mehanna H, Repanos C, Lancaster J, Roques T, Patel M, Sen M. Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):161-9.

Siddiqui MS, Chandra R, Aziz A, Suman S. Epidemiology and histopathological spectrum of head and neck cancers in Bihar, a state of Eastern India. Asian Pac J Cancer Prev. 2012;13(8):3949-53.

Dhull AK, Atri R, Dhankhar R, Chauhan AK, Kaushal V. Major Risk Factors in Head and Neck Cancer: A Retrospective Analysis of 12-Year Experiences. World J Oncol. 2018;9(3):80-4.

Nutting C. Radiotherapy in head and neck cancer management: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):66-7.

Yeh SA. Radiotherapy for Head and Neck Cancer. Semin Plast Surg. 2010;24.

Srinivasalu VK, Subramaniam N, Balasubramanian D, Kumar N, Philip A, Susan A, et al. Concurrent chemoradiotherapy for head and neck cancers in older patients: Outcomes and their determinants. Indian J Cancer. 2019;56(3):261-6.

Bartelink H, Van den Bogaert W, Horiot JC, Jager J, van Glabbeke M. Concomitant cisplatin and radiotherapy in a conventional and modified fractionation schedule in locally advanced head and neck cancer: a randomised phase II EORTC trial. Eur J Cancer. 2002;38(5):667-73.

Lohia N, Bhatnagar S, Singh S, Prashar M, Subramaniam A, Viswanath S, et al. Survival trends in oral cavity cancer patients treated with surgery and adjuvant radiotherapy in a tertiary center of Northern India: Where do we stand compared to the developed world? SRM J Res Dent Sci. 2019:10(1):26-31.

Costa Ade L, Araújo Júnior RF, Ramos CC. Correlation between TNM classification and malignancy histological feature of oral squamous cell carcinoma. Braz J Otorhinolaryngol. 2005;71(2):181-7.

Bryne M. Is the invasive front of an oral carcinoma the most important area for prognostication? Oral Dis. 1998;4:70-7.

Tshering P, Dorjee S, Dendup T, Dorji T, Wangmo D. Epidemiological and histopathological characteristics of head and neck cancers in Bhutan from 2011 to 2017: a retrospective descriptive study. Ecancermedicalscience. 2020;14:1024.