Prevalence of vitamin D deficiency in burn patients: an observational study

Rahul Gorka, Sakshi Bhat, Shalli Bavoria, Surbhi Dhar


Background: Burns are one of the most common and devastating forms of trauma in life. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality. Thermal injury creates a breach in the surface of the skin. It is difficult to evaluate the immediate effects of burn injury on serum levels of vitamin D metabolites because the binding proteins for 25-hydroxyvitamin D (25(OH)D), the main circulating form of the vitamin, and for 1,25-dihydroxyvitamin D (1,25(OH)2D) are low.

Methods: This study is a cross-sectional study. It was carried out in burn ward of Government medical college Jammu during June to November 2020. 52 burn patients of both sexes and all age groups were enrolled in this study.

Results: Fifty-two patients were evaluated in this study including 36 males and 16 females. In second degree superficial burns the mean level of 25(OH)D was 13.60 ng/ml (SD=7.27) ,in second degree deep burns the mean level of 25(OH)D was 13.88 ng/ml (SD=7.03) and in third degree burns the mean level of 25(OH)D was 14.71 ng/ml (SD=7.08).

Conclusions: Based on the results of this study, we can conclude that 25-hydroxyvitamin D levels are low in patients after acute burns, and these patients should be given vitamin D sup­plementation.


Burns, Vitamin D deficiency, Supplementation

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Church D, Elsayed S, Reid O, Winston B, Lindsay R. Burn wound infections. Clin Microbiol Rev. 2006; 19(2):403-34.

Raina K, Verma HN, Bhatia AS. Prevalence of vitamin D Deficiency in Jammu Region. JK Sci. 2014;16(1):21-3.

Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr .2004;79(3):362-71.

Ringe JD and Kipshoven C. Vitamin D-insufficiency An estimate of the situation in Germany. Dermato-Endocrinology. Landes Biosci. 2012;4(1):77-85.

Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-81.

Klein GL, Herndon DN, Goodman WG. Histomorphometric and biochemical characterization of bone following acute severe burns in children. Bone. 1995;17:455-60.

Klein GL, Chen TC, Holick MF. Synthesis of vitamin D in

skin after burns. Lancet. 2004;363:291-2.

Upala S, Sanguankeo A, Permpalung N. Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis. BMC Anesthesiol. 2015;15:84.

Ringe JD, Kipshoven C. Vitamin D-insufficiency: An estimate of the situation in Germany. Dermatoendocrinol. 2012;4(1):72-80.

Rodriguez NA, Jeschke MG, Williams FN, Kamolz LP, Herndon DN. Nutrition in burns: Galveston contributions. JPEN J Parenter Enteral Nutr. 2011; 35(6):704-14.

Klein GL et al. Standard multivitamin supplementation does not improve vitamin D insufficiency after burns. J Bone Miner Metab. 2009; 27(4):1-12.

Klein GL. Burns: where has all the calcium and vitamin D gone. Adv Nutr. 2011;2:457-62.

Sobouti B. Serum 25-hydroxyvitamin D levels in pediatric burn patients. Trauma Mon. 2016;21(1): e30905.

Chen LR. Additional vitamin and mineral support for patients with severe burns: a nationwide experience from a catastrophic color dust explosion event in Taiwan. Nutrients. 2018;10(11):1782.

Perez-Guisado J, de Haro-Padilla JM, Rioja LF, Derosier LC, de la Torre JI. Serum albumin levels in burn people are associated to the total body surface burned and the length of hospital stay but not to the initiation of the oral/enteral nutrition. Int J Burns Trauma. 2013;3(3):159-63.