DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20213521

Effectiveness of tramadol compared to pentazocine in pain management during labour

Bushra Bano, Kalavanti Bai, Shaista Jumani, Noreen Bashir, Humaira Mohsin, Saima Laghari, Haleema Yasmeen

Abstract


Background: Pain and agony during childbirth is quite often unbearable and at times beyond description. Pain relief can help in removing curb due to pain. To determine the efficacy of intramuscular tramadol hydrochloride as an analgesic during labor compared to those of pentazocine.

Methods: This randomized controlled trial conducted at Jinnah post graduate medical center, ward 8 (Gynaecology and obstetrics) between 2nd December 2013 to 1st June 2014 after approval from the ethical committee of the hospital. Pregnant women aged 15 to 45 years, parity ≥1 with Gestational age between 37 to 42 weeks with a single fetus were included in this study. The subjects fulfilling inclusion criteria were enrolled after informed consent. Women were allocated randomly to pentazocine or tramadol. Labour pain was assessed immediately by 4-point visual rating scale before, at 30, and 60 minutes after injection of the trial drug and mean score was calculated. The data was analysed using SPSS version 20.

Results: A total of 128 patients were randomized to ether tramadol or pentazocine. The mean age of enrolled participants is 30±7.01 years and 53.1% participants were below 30 years of age. Of 64 patients who received tramadol, 53 (82.8%) had pain relief compared to 39 (60.9%) in patient who received pentazocine (p=0.005).

Conclusions: It is concluded from this study that tramadol is more effective in reducing labor pain


Keywords


Pain, Pain relief, Labor, Tramadol, Pentazocine

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References


Subedi M, Bajaj S, Kumar MS, Mayur YC. An overview of tramadol and its usage in pain management and future perspective. Biomed Pharmacotherapy. 2019;111:443-51.

Vijayan R, Afshan G, Bashir K, Cardosa M, Chadha M, Chaudakshetrin P et al. Tramadol: a valuable treatment for pain in Southeast Asian countries. J Pain Res. 2018;11:2567-75.

Latthe P, Mignini L, Gray R, Hills R, Khan K. Factors predisposing women to chronic pelvic pain: systematic review. Br Med J. 2006;332(7544):749-55.

Longinus N. Ebirim, Buowari OY, Ghosh S. Physical and Psychological Aspects of Pain in Obstetrics, Pain in Perspective, Dr. Subhamay Ghosh (Ed.), 2012. Available at: http://www.intechopen.com/books/pain-in-perspective/physical-and-psychological-aspects-of-pain-in-obstetrics. Accessed on n12 Feb 2020.

Wahid S, Noreen U, Raza A, Hanif F, Waqas A. Ambulatory epidural analgesia for painless labour: Comparison between bupivacaine plus fentanyl and bupivacaine plus tramadol. Gomal J Med Sci. 2012;10(1):12-7.

Shafiq F, Hamid M, Samad K. Complications and interventions associated with epidural analgesia for postoperative pain relief in a tertiary care hospital. Middle East J Anesthesiol. 2010 Oct;20(6):827-32.

Ullman R, Smith L, Burns E, Mori R, Dowswell T. Parenteral opioids for maternal pain relief in labour. Cochrane Database Syst Rev. 2010;(9):CD007396.

Laidman J. Home Birth 10 Times More Likely to Result in Apgar of 0. Medscape. Available at: http://www.medscape.com/viewarticle/811222. Accessed September 24, 2013.

Kuti O, Faponle A, Adeyemi A, Owolabi A. Pain Relief in labour: A randomized controlled trial comparing pentazocine with Tramadol. Nepal J Obs Gynaecol. 2008;3(1):14-8.

Chandnani K, Sainee H. Pain relief in labour: tramadol versus pentazocine. Int J Reprod Contracept Obstet Gynecol. 2013;2(2):186-9.

East CE, Chan FY, Colditz PB. Fetal pulse oximetry for fetal assessment in labour. Cochrane Database Syst Rev. 2007;CD004075.

Tripti N, Jyotsna A. Pain relief in labor-tramadol versus pentazocin. Obstet Gynecol India. 2006;56(5):406-9

Prasertsawat PO, Herabutya Y, Chaturachinda K. Obstetrics analgesia. Curr Therap Res. 1986;40:1022-8.

Suvonnakote T, Thitadilok W, Atisook R. Pain relief during labour. J Med Assoc Thailand. 1986;69:576-80.

Lee CR, Mc Tavish D, Sorkin EM. Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic and therapeutic potential in acute and chronic pain states. Drugs. 1993;46(2);313-40.