Epidemiological determinants of age for effective cervical and breast cancer screening in menopausal women

Bharti Prakash, Meenakshi Gahlot, Laxmi Yadav


Background: Breast and cervical cancer screening play an important role in reducing cancer mortality. Family history and other screening tools are helpful in reducing cancer burden. Present study is focused on the impact of early screening of cervical and breast cancer on incidence of both cancers with focus on menopausal women ageing 30-70.

Methods:It is an epidemiological study in Ajmer municipal area with retrospective and prospective recorded data on cervical and breast cancer screening. Factors which are not considered may drive the observed association Participants of current study were registered and diagnosed with cervical and breast cancer in different hospital of Ajmer municipal area between January 2011-March 2015.468 women aged 30-70 with invasive cervical and breast cancer diagnosed in different major hospitals of Ajmer municipal area. Control participants were matched on area of residence and by age-group. Association between cancer and screening at particular ages are co-related to determine odd ratios.

Results: There is evidence that screening was associated with a 32% reduction of cervical cancer and 48% reduction of breast cancer in women aged 45.There is 41% reduction of cervical cancer and 52% reduction of breast cancer in women aged 55.There is no evidence of reduction in incidence of cervical and breast cancer at 35 (Odd Ratio 1.12, 95% confidence interval 0.84 to 1.52). Screening in later age reduces incidence and mortality from cervical and breast cancer.

Conclusions:To significantly reduce the breast and cervical cancer mortality, screening should be sturdily intensified to improve long term effectiveness. Quality assessment of early screening should be done via early indicators. New screening modalities have been introduced and some of them should be gradually incorporated into society practice.


Cancer screening, Cervical cancer, Breast cancer, Menopause

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Nelson HD, Tyne K, Naik A, Bougatsos C, Chan BK, Humphrey L. Screening for breast cancer: an update for the U.S. Preventive Services Task Force. Ann Intern Med. 2009;151(10):727-37, W237-42.

Decker D. Prophylactic Mastectomy for familial breast cancer. JAMA. 1993;269:2608-9.

Otto SJ, Fracheboud J, Looman CW, Broeders MJ, Boer R, Hendriks JH. Initiation of population-based mammography screening in Dutch municipalities and effect on breast-cancer mortality: a systematic review. Lancet. 2003;361(9367):1411-7.

Gallicchio L, McSorley MA, Newschaffer CJ, Huang HY, Thuita LW, Hoffman SC, et al. Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease. Cancer Detect Prev. 2007;31(2):95-101.

Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA. 1996;93(13):6231-5.

Kaklamani VG, Sadim M, Hsi A, Offit K, Oddoux C, Ostrer H, et al. Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk. Cancer Res. 2008;68(9):3178-84.

Liu CL, Chang YC, Cheng SP, Chern SR, Yang TL, Lee JJ, et al. The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon109 in breast cancer. Oncology. 2007;72(1-2):75-81.

Mantzoros C, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe DM, et al. Adiponectin and breast cancer risk. J Clin Endocrinol Metab. 2004;89(3):1102-7.

Elwood, J. M., B. Cox, and A. K. Richardson. The effectiveness of breast cancer screening by mammography in younger women. The Online journal of current clinical trials (1993): 23-227.

Oleckno WA. Essential Epidemiology: Principles and applications. long Grove II: Waveland Press; 2002.

Snoussi K, Strosberg AD, Bouaouina N, Ben Ahmed S, Helal AN, Chouchane L. Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. BMC Cancer. 2006;6:38.

Szklo M, Nieto FJ .Epidemiology: Beyond the besics. 2nd edition. Sudbury, MA: Jones and Bartlett Publishers; 2007.

Takahata C, Miyoshi Y, Irahara N, Taguchi T, Tamaki Y, Noguchi S. Demonstration of Adiponectin Receptors 1 and 2 mRNA expression in human breast cancer cells. Cancer Lett. 2006;54(13):113-9.

Tworoger SS, Eliassen AH, Kelesidis T, Colditz GA, Willett WC, Mantzoros C, et al. Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab. 2007;6(23)119-21.