DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20204339

Effect of telephone calls and text message reminder interventions on the adherence to antiretroviral drugs among HIV/AIDS clients receiving care in Sokoto state, Nigeria

Remi A. Oladigbolu, Mansur O. Oche, Mansur O. Raji, Godwin J. Gana, Zainab A. Ezenwoko

Abstract


Background: Adherence to antiretroviral therapy (ART) has been proven to be a good predictor of clinical outcome among patients on ART. This study aimed to assess the effect of phone reminder interventions on the knowledge of Human immunodeficiency syndrome (HIV)/ Acquired immunodeficiency syndrome (AIDS), ART and adherence to ART drugs among non-adherent patients receiving care in Sokoto State.

Methods: A quasi-experimental study was conducted among 196 non-adherent HIV patients between February and July 2017. The intervention group received monthly telephone calls and weekly text messages for twelve weeks while the control group received only standard of care. Self-report adherence, forgetfulness to take ART and knowledge of HIV/AIDS and ART were measured pre- and post- intervention. Data were processed and analysed using IBM Statistical package for social sciences (SPSS) version 22 computer statistical software package.

Results: At baseline, although majority of participants in both groups had good knowledge of HIV/AIDS, ART drug adherence, they were both non-adherent to ART and it was mainly due to forgetfulness. At post intervention, respondents with good knowledge and adherent to ART were significantly higher in the intervention group. There was also a significantly lower proportion of forgetfulness among the intervention group compared with control group (c2=47.57, p<0.001).

Conclusion: The interventions were found to be effective. The Federal Ministry of Health (FMoH) with the support of implementing partners need to integrate these interventions into clinical setting as part of comprehensive care for HIV care and treatment to assist in improving their knowledge of HIV/AIDS, ART and adherence to ART.


Keywords


Non-adherence, ART, HIV/AIDS, Telephone call, Text message reminders, Sokoto

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References


Awofala AA, Ogundele OE. HIV epidemiology in Nigeria. Saudi Journal of Biological Sciences. 2018;25(4):697-703.

World Health Organization. Fact Sheet. Global Update on the Health Sector Response to HIV, Geneva. 2014;3-6. Last accessed on 20 May 2020.

NACA. National Strategic Framework on HIV and AIDS: 2017-2021. 2017. Last accessed on 20 May 2020.

Joint United Nations Programme on HIV and AIDS. Prevention Gap Report. 2016:8-10. Last accessed on 20 May 2020.

PEPFAR. Large National Survey Shows Smaller HIV Epidemic in Nigeria Than Once Thought and Highlights Key Gaps Toward Reaching HIV Epidemic Control'. 2019. Last accessed on 20 April 2019.

Okoronkwo I, Okeke U, Chinweuba A, Iheanacho P. Non-adherence Factors and Sociodemographic Characteristics of HIV-Infected Adults Receiving Antiretroviral Therapy in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. ISRN AIDS ISRN AIDS. 2013;2013(8):1-8.

Chesney MA. Factors Affecting Adherence to Antiretroviral Therapy. Clin Infect Dis. 2000;30(2):S171-6.

Olowookere SA, Fatiregun AA, Akinyemi JO, Bamgboye AE, Osagbemi GK. Prevalence and Determinants of Non-adherence to Highly Active Antiretroviral Therapy among People Living with HIV/AIDS in Ibadan, Nigeria. J Infect Dev Ctries. 2008;2(5):369-72.

Pennap G, Abdullahi U, Bako I. Adherence to Highly Active Antiretroviral Therapy and Its Challenges in People Living with Human Immunodeficiency Virus (HIV) Infection in Keffi, Nigeria. Journal of AIDS and HIV Research. 2013;5(2):52-8.

Uzochukwu BS, Onwujekwe OE, Onoka AC, Okoli C, Uguru NP, Chukwuogo OI. Determinants of Non-Adherence to Subsidized Anti-Retroviral Treatment in Southeast Nigeria. Health Policy Plan. 2009;24(3):189-96.

Orrell C, Bangsberg DR, Badri M, Wood R. Adherence is Not a Barrier to Successful Antiretroviral Therapy in South Africa. Aids. 2003;17(9):1369-75.

Nachega JB, Hislop M, Dowdy DW, Lo M, Omer SB, Regensberg L, et al. Adherence to Highly Active Antiretroviral Therapy Assessed by Pharmacy Claims Predicts Survival in HIV-Infected South African Adults. J Acquir Immune Defic Syndr. 2006;43(1):78-84.

Graham SM, Masese L, Gitau R, Jalalian-Lechak Z, Richardson BA, Peshu N, et al. Antiretroviral Adherence and Development of Drug Resistance Are the Strongest Predictors of Genital HIV-1 Shedding among Women Initiating Treatment. J Infect Dis. 2010;202(10):1538-42.

Gifford AL, Shively MJ, Bormann JE, Timberlake D, Bozzette SA. Self-Reported Adherence to Combination Antiretroviral Medication Regimens in a Community-Based Sample of HIV-Infected Adults [Abstract 32338]. In: Program and Abstracts of the 12th World AIDS Conference. Geneva: Marathon Multimedia. 1998.

Klosinski LE, Brooks RN. Predictors of Non-Adherence to HIV Combination Therapies [Abstract 32375]. In: Program and Abstracts of the 12th World AIDS Conference. Geneva: Marathon Multimedia. 1998.

Paterson DL, Swindels S, Mohr JA. Adherence with Protease Inhibitor Therapy for Human Immunodeficiency Virus Infection [Abstract I-172]. In: Program and Abstracts of the 38th Interscience Conference on Antimi-Crobial Agents and Chemotherapy (San Diego). Washington, DC. American Society for Microbiology. 1998;97-105.

Scott-Lennox J, Braun JF, Morrow JE, Lawson K, Tirelle R, Dietrih D. Development of the HIV Treatment Satisfaction Survey (HTSS) to Improve Adherence and Quality of Outpatient Care [Abstract 12445]. In: Program and Abstracts of the 12th World AIDS Conference. Geneva: Marathon Multimedia. 1998:10-3.

Taiwo BO, Idoko JA, Welty LJ, Otoh I, Job G, Iyaji PG, et al. Assessing the Viorologic and Adherence Benefits of Patient-Selected HIV Treatment Partners in a Resource-Limited Setting. J Acquir Immune Defic Syndr. 2010;54(1):85-92.

Roux P, Kouanfack C, Cohen J, Marcellin F, Boyer S, Delaporte E, et al. Adherence to Antiretroviral Treatment in HIV-Positive Patients in the Cameroon Context: Promoting the Use of Medication Reminder Methods. J Acquir Immune Defic Syndr. 2011;57 (1):S40-3.

Pop-Eleches C, Thirumurthy H, Habyarimana JP, Zivin JG, Goldstein MP, de Walque D, et al. Mobile Phone Technologies Improve Adherence to Antiretroviral Treatment in a Resource-Limited Setting: a Randomized Controlled Trial of Text Message Reminders. Aids. 2011;25(6):825-34.

Rodrigues R, Shet A, Antony J, Sidney K, Arumugam K, Krishnamurthy S, et al. Supporting Adherence to Antiretroviral Therapy with Mobile Phone Reminders: Results from a Cohort in South India. PLoS ONE. 2012;7(8):e40723.

Hardy H, Kumar V, Doros G, Farmer E, Drainoni ML, Rybin D, et al. Randomized Controlled Trial of a Personalized Cellular Phone Reminder System to Enhance Adherence to Antiretroviral Therapy. AIDS Patient Care STDS. 2011;25(3):153-61.

Ogunbanjo GA, Heyer A. Adherence to HIV Antiretroviral Therapy Part Ii: Which Interventions are Effective in Improving Adherence? SA Fam Pract. 2006;48(9):6-10.

Amico KR, Harman JJ, Johnson BT. Efficacy of Antiretroviral Therapy Adherence Interventions: A Research Synthesis of Trials, 1996 to 2004. J Acquir Immune Defic Syndr. 2006;41(3):285-97.

Ibrahim MTO. Sample size determination. In: 1st, editor. Research Methodology and Dissertation writing for Health & Allied Health Professionals. Nigeria: Cress Global Link Limited, Abuja. 2009;70-102.

Araoye MO. Subject Selection. Research Methodology with Statistics for Health and Social Sciences. Ilorin: Nathadex Publishers. 2003;121.

Fong OW. Adherence to HI V Treatment. [online]. Department of Public Health: Hong Kong, China 2006. Available from: http://www.info.gov.hk/aids/ pdf/g190htm/13.htm#1. Last accessed on

Sharaf AY, Ibrahim AFAE-F, Elhamami M. Knowledge and Adherence to Oral Anticoagulant Therapy among Patients with Mechanical Heart Valve Prosthesis. IOSR Journal of Nursing and Health Science. 2017;6(3):19-29.

Bangsberg D, Moss AR, Deeks SG. Paradoxes of Adherence and Drug Resistance to HIV Antiretroviral Therapy. The Journal of antimicrobial chemotherapy. 2004;53(5):696-9.

Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, et al. Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection. Ann Intern Med. 2000;133(1):21-30.

Simoni JM, Frick PA, Pantalone DW, Turner BJ. Antiretroviral Adherence Interventions: A Review of Current Literature and Ongoing Studies. Top HIV Med. 2003;11(6):185-98.

Kasumu LO, Balogun MR. Knowledge and attitude towards antiretroviral therapy and adherence pattern of HIV patients in southwest Nigeria. International Journal of Infection Control. 2014;10:13.

Boateng D, Kwapong G, Agyei-Baffour P. Knowledge, Perception About Antiretroviral Therapy (ART) and Prevention of Mother-to-Child-Transmission (PMTCT) and Adherence to ART among HIV Positive Women in the Ashanti Region, Ghana. BMC Women's Health. 2013;13:2.

Nachega JB, Lehman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, Karstaedt AS. HIV/AIDS and Antiretroviral Treatment Knowledge, Attitudes, Beliefs, and Practices in HIV-Infected Adults in Soweto, South Africa. J Acquir Immune Defic Syndr. 2005;38(2):196-201.

Awosan KJ, Ibrahim MTO, Arisegi SA, Erhiano EE. Knowledge of HIV/AIDS, risk perception, sexual lifestyle and condom use among drivers in Sokoto, Nigeria. Journal of Infectious Diseases and Immunity. 2014;6(3):19-25.

Mugoyelaand V, Charles V. Knowledge of HIV/AIDS and preventive measures use by city commuter-bus drivers and conductors in Dar Es Salaam, Tanzania. East Afr J Pub Hlth. 2009;6(1):73-6.

Singh RK, Joshi HS. Sexual behavior among truck drivers. Ind J Pub Hlth. 2012;56(1):53-6.

Olowookere SA, Fatiregun AA, Adewole IF. Knowledge and Attitudes Regarding HIV/AIDS and Antiretroviral Therapy among Patients at a Nigerian Treatment Clinic. J Infect Dev Ctries. 2012;6(11):809-16.

Onyeonoro U, Ukegbu A, Ebenebe U, Emelumadu O, Ibeh C, Nwamoh U. Adherence to Antiretroviral Therapy among People Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome in a Tertiary Health Facility in South Eastern Nigeria. J HIV Hum Reprod Journal of HIV and Human Reproduction. 2013;1(2):58.

Maduka O, Tobin-West CI. Adherence Counseling and Reminder Text Messages Improve Uptake of Antiretroviral Therapy in a Tertiary Hospital in Nigeria. Niger J Clin Pract. 2013;16(3):302-8.East Asian J Trop Med Public Health. 2013;44(2):1-5.