Clinical features, laboratory profile and outcomes among dengue patients admitted in a tertiary care hospital, Delhi NCR

Mohit Tiwari, Abhishek Tibrewal, Varun S. Pichika


Background: Globally, dengue, a mosquito-borne viral infection, is the most rapidly spreading vector-borne disease. Dengue fever is endemic in >100 countries including India. Dengue has a variety of clinical presentations. The objective of the study was to understand the clinical features, laboratory profile and outcomes of dengue fever among patients admitted in a tertiary care hospital in Delhi, National Capital Region.

Methods: This was a cross-sectional study among 75 dengue confirmed (NS-1 antigen and/or IgM antibody positive) patients with fever <1 week. The variables included were socio-demographic; clinical features; laboratory and radiological profile and outcomes. Descriptive analysis was used.

Results: The majority of the patients were aged between 18-40 years 72% and predominantly males 68%. A total of 18.7% patients (malaria: 13.3% and chikungunya: 5.3%) had co-infection. Fever was present in all the patients, followed by myalgia (74.7% patients), retro-orbital pain/headache 69.3%, and vomiting 45.3%. The mean hemoglobin was 13.9 gm/dl, leukopenia 46.7% patients, thrombocytopenia 96.0% and elevated liver enzymes 69.3%. Radiological examination showed pleural effusion 6.7%, gallbladder wall thickening 6.7%, splenomegaly 4.0%, and hepatomegaly 2.7%. The outcomes included ICU care 17.3%, ventilator support 13.3%, blood transfusion 14.7%, and mortality 1.3% during the hospital stay.

Conclusions: Dengue has become a major public health problem in India. The most common clinical features are fever, myalgia, headache and vomiting; laboratory abnormalities are leukopenia, thrombocytopenia and deranged liver enzymes. No specific treatment exists, but early detection and proper medical care lowers fatality rates.



Dengue, Clinical features, Laboratory, Outcomes, Delhi

Full Text:



Stanaway JD, Shepard DS, Undurraga EA. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013. Lancet Infect Dis. 2016;16:712-23.

WHO. Home/Newsroom/Fact sheets/Detail/Dengue and severe dengue. Available at Accessed on 10 May 2010.

World Health Organization. Geneva, Switzerland: WHO. Dengue: guidelines for diagnosis, treatment, prevention and control; 2009.

Murhekar MV, Kamaraj P, Kumar MS, Khan SA, Allam RR, Barde P, et al. Burden of dengue infection in India, 2017: a cross-sectional population based serosurvey. Lancet Global Health. 2019;7.

National Vector borne Disease Control Program. Dengue/DHF situation in India. Available at Accessed on 10 May 2020.

Bäck AT, Lundkvist A. Dengue viruses - an overview. Infect Ecol Epidemiol. 2013;3:10.

Dinkar A, Singh J. Dengue infection in North India: An experience of a tertiary care center from 2012 to 2017. Tzu Chi Med J. 2020;32:36-40.

Chatterjee N, Mukhopadhyay M, Ghosh S, Mondol M, Das C, Patar K. An Observational Study of Dengue Fever in a Tertiary Care Hospital of Eastern India. J Assoc Physicians India. 2014;62(3):224-7.

Madan SP, Bhatawadekar S, Lahiri K. Clinico-demographic profile and seroprevalence of dengue at a tertiary care hospital- study from Maharashtra. Int J Health Sci Res. 2018;8(1):43-8.

Kumar A, Rao CR, Pandit V, Shetty S, Bammigatti C, Samarasinghe CM. Clinical manifestations and trend of dengue cases admitted in a tertiary care hospital, Udupi district, Karnataka. Indian J Community Med. 2010;35(3):386-90.

Doke PP, Pawar S. Profile of Dengue Fever outbreaks in Maharashtra. Indian J Community Med. 2000;25(4):170-6.

Kumar M, Sharma R, Parihar G, Sharma M. Seroprevalence of Dengue in Central Rajasthan: A Study at a Tertiary Care Hospital. Int J Curr Microbiol App Sci. 2015;4(9):933-40.

Deshwal R, Qureshi MI, Singh R. Clinical and Laboratory Profile of Dengue Fever. J Association Physicians India. 2015;63.

Gajera VV, Sahu S, Dhar R. Study of Haematological Profile of Dengue Fever and its Clinical Implication. Annals Applied Bio-Sci. 2016;3(3):2455-396.

Meena KC, Jelia S, Meena S, Arif M, Ajmera D, Jatav VS. A study of hematological profile in dengue fever at a tertiary care center, Kota Rajasthan. Int J Adv Med. 2016;3(3):621-24.

Complete Blood Count (CBC) Test. Available at Accessed on 20 May 2020.

Chaloemwong J, Tantiworawit A, Rattanathammethee T, Hantrakool S, Chai-Adisaksopha C, Rattarittamrong E, et al. Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective study. BMC Hematology. 2018;18:20.

Samanta J, Sharma V. Dengue and its effects on liver. World J Clin Cases. 2015;3(2):125-31.

Davis CP. Liver Blood Tests (Normal, Low, and High Ranges and Results). Available at Accessed on 20 May 2020.

Mandal SK, Ganguly J, Sil K, Chatterjee S, Chatterjee K, Sarkar P, et al. Clinical profile of dengue fever in teaching hospital in Eastern India. Nat J Med RES. 2013;3:173-76.

Santhosh VR, Patil PG, Srinath MG, Kumar A, Jain A, Archana M. Sonography in the diagnosis and assessment of dengue Fever. J Clin Imaging Sci. 2014;4:14.

Vulavala S, Reddy Y, Kamarthy P. Study of clinical and laboratory profile of Dengue fever patients. EJPMR. 2016;3(11):613-16.