Use of hydroxychloroquine for novel corona virus infection in India: is it ethically justifiable?
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20202052Keywords:
Corona virus, COVID-19, Hydroxychloroquine, Side effects, ProphylaxisAbstract
Coronavirus disease is caused by a novel virus belonging to the family of corona viruses similar to severe acute respiratory syndrome (SARS) and name given to the novel virus as SARS Coronavirus- 2 (SARS-CoV-2) and the disease was named as COVID-19 on 11th February 2020 by World Health Organization (WHO). First case of this infection was reported in December 2019 in Wuhan city of China and after that it spread globally.3 On 30th January 2020, WHO declared this disease as Public Health Emergency of International Concern (PHEIC) and on 11th March 2020, WHO declared it as a pandemic when the infection was reported from all six WHO regions.
References
Coronavirus disease 2019 (COVID-19). Symptoms and causes. Mayo Clinic. Available at: https://www. mayoclinic.org/diseases-conditions/coronavirus/ symptoms-causes/syc-20479963. Accessed on 25 April 2020.
Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264-6.
WHO Director-General's opening remarks at the media briefing on COVID-19. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed on 15 April 2020.
Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV)". World Health Organization (WHO). 2020 Available at: https://www.who.int/news-room/ detail/30-01-2020-statement-on-the-second-meeting -of-the-international-health-regulations-(2005)-em-ergency-committee-regarding-the-outbreak-of-nov-el-coronavirus-(2019-ncov). Accessed on 15 April 2020.
Q&A on corona viruses (COVID-19). World Health Organization (WHO). Available at: https://www. who.int/news-room/q-a-detail/q-a-coronaviruses. Accessed on 24 April 2020.
How COVID-19 Spreads. Centers for Disease Control and Prevention (CDC). Available at: https://www.cdc.gov/coronavirus/2019-ncov/faq. html. Accessed on 24 April 2020.
Q & A on COVID-19. European Centre for Disease Prevention and Control. Available at: https://www. ecdc.europa.eu/en/covid-19/questions-answers. Accessed on 15 April 2020.
COVID-19 Corona Virus Pandemic. Available at: https://www.worldometers.info/coronavirus/. Accessed on 25 April 2020.
COVID-19 India, Ministry of Health and Family welfare Govt of India. Available at: https://www. mohfw.gov.in/ Accessed on 24 April 2020.
Fisher D, Heymann D. Q&A: The novel coronavirus outbreak causing COVID-19. BMC Med. 2020;18(1):57.
Advisory on the use hydroxyl-chloroquine as a prophylaxis for SARS C0-2. Available at: https://www.mohfw.gov.in/pdf/Advisoryonthe useofHydroxychloroquinasprophylaxisforSARSCoV2 infection.pdf. Accessed on 25 April 2020.
The Hindu, Govt approves use of hydroxychloroquine with azithromycin for critical COVID-19 patients. Available at: https://www.the hindu.com/news/national/health-ministry-allows-hydroxychloroquine-with-azithromycin-for-covid-19/article31221659.ece. Accessed on 15 April 2020.
Savarino A, Boelaert JR, Cassone A, Majori G, Cauda R. Effects of chloroquine on viral infections: an old drug against today's diseases? Lancet Infect Dis. 2003;3:722-7.
Science the war. Does pandemic justify using HCQ to beat the corona virus?. Available at: https://science.thewire.in/health/coronavirus-covid-19-hydroxychloroquine-icmr-guidelines-long-qt-syndrome. Accessed on 17 April 2020.
The First post Use hydroxychloroquine for high-risk COVID-19 cases, recommends ICMR; drug to be used only as preventive measure: All you need to know. 7th April 2020. Available at: https://www. firstpost.com/health/coronavirus-outbreak-use-hydroxychloroquine-for-high-risk-covid-19-cases-recommends-icmr-drug-to-be-used-only-as-preventive-measure-all-you-need-to-know-8179771. html. Accessed on 25 April 2020.
Touret F, de Lamballerie X. Of chloroquine and COVID-19. Antiviral Res. 2020;177:104762.
Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov. 2020;6:16.
The Economics Times. 26th March 2020. Available at: https://economictimes.indiatimes.com/industry/ healthcare/biotech/pharmaceuticals/the-drug-thats-leading-the-fight-against-coronavirus/so-what-are-these-drugs/slideshow/74823024.cms. Accessed on 22 April 2020.
Frellick M. No Hydroxychloroquine Benefit in Small, Randomized COVID-19 Trial. Medscape, 2020. Available at: https://www.medscape.com/ viewarticle/928798. Accessed on 25 April 2020.
Business Standard 22nd April 2020. Plan to use HCQ for Covid-19 treatment receives setback after death reports. Available at: https://www.business-standard.c om/article/international/plan-to-use-hcq-for-covid-19-treatment-receives-setback-after-death-reports-120042200190_1.html. Accessed on 24 April 2020.
Money Control news. Moneycontrolcom. Available at: https://www.moneycontrol.com/news/ world/fdi-warns-against-consuming-chloroquine-hcq-to-treat-covid-19-after-deaths-serious-poisoning-reported-5187631.html. Accessed on 25 April 2020.
The Los Angles Times. Malaria drugs fail to help coronavirus patients in controlled studies. Available at: https://www.latimes.com/science/story/2020-04-17/malaria-drugs-fails-to-help-coronavirus-patients-in-controlled-studies. Accessed on 23 April 2020.
News18. Covid-19: ICMR Conducting Observational Study on Anti-malarial Drug Hydroxychloroquine. Available at: https://www. news18.com/news/india/covid-19-icmr-conducting-observational-study-on-anti-malarial-drug-hydroxychloroquine-2583333.html. Accessed on 21 April 2020.
Deccan Herald. Available at: https://www.deccan herald.com/national/covid-19-icmr-launches-study-on-side-effects-of-hydroxychloroquine-827114. html. Accessed on 20 April 2020.
