Dietary intake of mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotype (w/v)

Authors

  • ML Edy Parwanto Department of Biology, Faculty of Medicine, University of Trisakti, Jakarta, Indonesia
  • Hardy Senjaya Department of Anatomy, Faculty of Medicine, University of Trisakti, Jakarta, Indonesia

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20170264

Keywords:

BMI, Bbs-I enzyme, CED, Dietary intake, SHBG genetic polymorphism

Abstract

Background: Body mass index (BMI) determined by genetic and environmental factors. One of the genetic factors that determine the BMI is a genetic polymorphism of sex hormone binding globulin (SHBG), whereas the intake of nutrients is one of the environmental factors. The objective: investigate to macronutrient intake of mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotype (W/v).

Methods: Anthropometric measurement, genotyping of D327N SHBG gen exon 8, and three days repeated food recall and record was done for all subjects. BMI in the group I 16 to <17 kg/m2 and group II 17 to <18.5 kg/m2. For all subjects in both groups has heterozygous variant D327N SHBG genotype (W/v).

Results: mother in chieldbearing age with BMI <18.5 kg/m2 and has heterozygous variant SHBG genotype (W/v) is undernutrition. Seventy two percent of the total subjects including type I of chronic energy deficiency (CED), and 28% as type II of CED. Protein, fat and carbohydrate intake and mid-upper arm circumference (MUAC) in the group I was lower than group II (p<0.05), while muscle mass in the group I did not different compare to group II (p>0.097).

Conclusions: Mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotypes (W/v) shows that the lower of protein, fat and carbohydrate intake then CED status is getting low.

References

Segal NL, Feng R, McGuire SA, Allison DB, Miller S. Genetic and environmental contributions to body mass index: comparative analysis of monozygotic twins, dizygotic twins and same-age unrelated siblings. Int J Obes (Lond). 2009;33(1):37-41.

Parwanto E. The influence of lipid-protein intake and sex hormone binding globulin (SHBG) polymorphism on the levels of SHBG at Indonesian and Caucasian men (in Indonesian language). Disertation, Faculty of Medicine, University of Indonesia. 2004.

Iranzo-Tatay C, Gimeno-Clemente N, Livianos-Aldana L, Rojo-Moreno L. Genetic and environmental contributions to body mass index in a Spanish adolescent twin sample. Med Clin (Barc). 2014;pii: S0025-7753(14)00467-9. doi: 10.1016/j.medcli.2014.05.039.

Power SG, Bocchimfuso WP, Pallesen M, Warmeis-Rodenhiser S, Van Baelen H and Hammond GL. Molecular analysis of human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain. J Clin Endocrinol Metab. 1992;75:1066-70.

Klee GG, Heser DW. Techniques to Measure Testosterone in the Elderly. Mayo Clin Proc. 2000;75(Suppl):S19-S25.

Delehanty B, Hossain S, Jen CC, Crawshaw GJ, Boonstra R. Measurement of free glucocorticoids: quantifying corticosteroid-binding globulin binding affinity and its variation within and among mammalian species. Conserv Phys. 2015;3:1-13.

Brand JS, van der Tweel I, Grobbee DE, Emmelot-Vonk MH and van der Schouw YT. Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies. Int J Epid. 2011;40:189-207.

Hryb DJ, Khan MS, Romas NA and Rosner W. The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones. J Biol Chem. 1990;265:6048-54.

Riancho JA, Valero C, Zarrabeitia MT, García-Unzueta MT, Amado JA and González-Macías J. Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women. BMC Med Gen. 2008;9(112):1-6.

Cousin P, DéChaud H, Grenot C, Lejeune H, Pugeat M. Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit. J Clin Endocrinol Metab. 1998;83(1):235-40.

Basaria S, Coviello AD, Travison TG, Storer TW, Farwell WR, Jette AM, et al. Adverse events associated with testosterone administration. N Engl J Med. 2010;363(2):109-122.

Kahn SM, Hryb DJ, Nakhla AM, Romas NA and Rosner W. Beyond carrier proteins: Sex hormone-binding globulin is synthesized in target cells. J Endocrinol. 2002;175:113-20.

Parwanto E, Indrawati Y, Setiawan H. Isoflavone supplementation reduced serum sex hormone binding globulin concentration in postmenopausal women. Univ Med. 2012;31(1):52-62.

Kalsum U, Sutrisna B, Djuwita R, Achadi EL, Jahari AB. A new alternative indicator for chronic energy deficiency in women of childbearing age in Indonesia. Health Sci Indones. 2014;2:54-9.

Kulasekaran RA. Influence of mothers’ chronic energy deficiency on the nutritional status of preschool children in Empowered Action Group states in India. Int J Nutr Pharmacol Neurol Dis. 2012;2(3):198-209.

Balitbangkes (Badan Penelitian dan Pengembangan Kesehatan) Kementrian Kesehatan RI. Riset Kesehatan dasar (RISKESDAS). 2010.

Shay CM, Van Horn L, Stamler J, Dyer AR, Brown IJ, Chan Q et al. Food and nutrient intakes and their associations with lower BMI in middle-aged US adults: the International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP). Am J Clin Nutr. 2012;96:483-91.

Thomas L. Clinical Laboratory Diagnostics. 1st ed. Frankfurt: TH-Books Verlagsgesellschaft. 1998:131-7.

NCEP (National Cholesterol Education Program), National Heart, Lung, and Blood Institute National Institutes of Health. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. NIH Publication, 2002; Sept No. 02-5215.

Deepti GI, Shetty S, Rao AV, Ahmad S. Age related difference in the lipid profile in normal healthy women. Nitte University J Health Sci. 2014;4(2):94-7.

Ishizuka M, Nagata H, Takagi K, Horie T, Kubota K: Inflammation-based prognostic score is a novel predictor of postoperative outcome in patients with colorectal cancer. Ann Surg. 2007;246:1047-51.

Begum JA, Sultana R and Naher S. Serum levels of total protein, albumin and globulin in women with hyperemisis gravidarum. J Dhaka Med Coll. 2010;19(1):58-60.

Pryer JA, Rogers S. Epidemiology of undernutrition in adults in Dhaka slum households, Bangladesh. Eur J Clin Nutr. 2006;60:815-22.

Parwanto MLE, Suweino S, Tjahjadi D, Senjaya H, Edy HJ, Pakpahan A. The effect of sex hormone binding globulin (SHBG) protein polymorphism on the levels of SHBG, testosterone, and insulin in healthy Indonesian men. Int J Med Sci Public Health. 2016;5:799-806.

WHO (World Health Organization). Physical status: The use and interpretation of anthropometry. Technical Report Series No. 854. Geneva 1995.

Abraham S, Miruts G and Shumye A. Magnitude of chronic energy deficiency and its associated factors among women of reproductive age in the Kunama population, Tigray, Ethiopia, in 2014. BMC Nutr 2015;1(12):1-9.

Pelletier DL, Frongillo EA. Changes in child survival are strongly associated with changes in malnutrition in developing countries. J Nutr. 2003;133:107-19.

Villamor E, Msamanga G, Spiegelman D, Peterson KE, Antelman G, Fawzi WW. Pattern and Predictors of Weight Gain during Pregnancy among HIV-1-Infected Women from Tanzania. JAIDS: J Acq Imm Def Syndr. 2003;32(5):560-9.

Verhoeff FH, Brabin BJ, van Buuren S, Chimsuku L, Kazembe P, Wit JM, et al. An analysis of intra-uterine growth retardation in rural Malawi. Eur J Clin Nutr. 2001;55(8):682-9.

Chakraborty R, Bose K, Bisai S. Mid-Upper Arm Circumference as a Measure of Nutritional Status among Adult Bengalee Male Slum Dwellers of Kolkata, India: Relationship with Self-Reported Morbidity. Anthropol Anz. 2009;67(2):129-37.

Abrhame T, Haidar J. The sensitivity and specificity of mid-upper arm circumference compared to body mass index in screening malnutrition of adult HIV patients taking ART; evidence from selected facilities of Addis Ababa, Ethiopia. Sci J Publ Health. 2014;3(1):19-24.

Jelena J, Baltic ZM, Milica G, Jelena I, Marija B, Milka P, Mirjana L. Relationship between Body Mass Index and Body Fat Percentage among Adolescents from Serbian Republic. J Childhood Obes. 2016;1(2):1-5.

Scott D, Blizzard L, Fell J, Giles G and Jones G. Associations between dietary nutrient intake and muscle mass and strength in community-dwelling older adults: the Tasmanian Older Adult Cohort Study. J Am Geriatr Soc. 2010;58(11):2129-34.

Calvani R, Martone AM, Marzetti E, Onder G, Savera G, Lorenzi M, et al. Pre-hospital dietary intake correlates with muscle mass at the time of fracture in older hip-fractured patients. Front Aging Neurosci. 2014;6(269):1-6.

Pencharz PB, Elango R, Wolfe RR. Recent developments in understanding protein needs – How much and what kind should we eat? Appl Physiol Nutr Metab. 2016;41:577-80.

Nande PJ. Anthropometric measurements, dietary intake and lipid profile of hypertensive young adults (25-35 years): a comparison between vegetarians and non vegetarians. Curr Res Nutr Food Sci. 2014;2(3):122-30.

Ramakrishnan U. Nutrition and low birth weight: from research to practice. Am J Clin Nutr. 2004;79(1):17-21.

Shawky S, Milaat W. Early teenage marriage and subsequent pregnancy outcome. East Mediterr Health J. 2000;6(1):46-54.

Sallinen J, Pakarinen A, Ahtiainen J, Kraemer WJ, Volek JS, Häkkinen K. Relationship between diet and serum anabolic hormone responses to heavy resistance exercise in strength athletes and physically active males. Int J Sports Med. 2004;25:627-33.

Berrino F, Bellati C, Secreto G, Camerini E, Pala V, Panico S et al. Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial. Cancer Epidemiol Biomarkers Prev. 2001;10(1):25-33.

Downloads

Published

2017-01-25

How to Cite

Parwanto, M. E., & Senjaya, H. (2017). Dietary intake of mother in childbearing age with BMI <18.5 kg/m2 and has heterozygous variant D327N SHBG genotype (w/v). International Journal Of Community Medicine And Public Health, 4(2), 409–417. https://doi.org/10.18203/2394-6040.ijcmph20170264

Issue

Section

Original Research Articles