Urinary tract Infection among type 2 diabetic patients admitted in a multispecialty hospital in South Chennai, Tamil Nadu

P. S. Vignesh, T. T. Gopinath, D. K. Sriram


Background: Diabetes mellitus (DM) is a chronic and potentially disabling disease which is reaching an epidemic proportion in many parts of the world. UTI is a common infection observed in diabetic patients. The objectives of this study was to determine the prevalence of UTI among hospitalized type 2 diabetic patients, the frequent bacteria responsible for UTI and most susceptible antibiotics among the diabetic patients.

Methods: A hospital-based study involving type 2 diabetes patients admitted with diagnosis of UTI between 2017- 2018 (July - June). The study was a cross sectional study and was approved by the Ethics Committee of the hospital. Patients fitting study inclusion and exclusion criteria took part in the study with informed written consent obtained. A validated pilot-tested questionnaire was used as a tool for data collection.

Results: Total of 126 subjects were identified. Prevalence of UTI was around 25% higher in women with type 2 diabetes than in men. UTI was found to be significantly associated with age, creatinine (p<0.05) and Escherichia coli was the commonly isolated micro-organism. The gram negative pathogens were highly sensitive to cefoperazone-sulbactum and amikacin was found to be the most sensitive antibiotic for both gram positive and gram negative pathogens.

Conclusions: UTIs are frequent in diabetic patients. Improved glycemic control in diabetics may help in controlling the UTIs. Accurate screening for UTI in diabetic patients is also critical to enable the appropriate treatment and avoiding related complications.


Type 2 diabetes mellitus, UTI, Amikacin

Full Text:



Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;103(2):137–49.

Patterson JE, Andriole VT. Bacterial urinary tract infections in diabetes. Infect Dis Clin North Am. 1997;11(3):735–50.

De-Aguia LG, Carneiro JR, Ginzbarg D, Cunha EF, Gomes MB. Infection in hospitalized diabetics. Rev Assoc Med Bras. 1997;43:314-8.

Kofteridis DP, Papadimitraki E, Mantadakis E, Maraki S, Papadakis JA, Tzifa G, et al. Effect of diabetes mellitus on the clinical and microbiological features of hospitalized elderly patients with acute pyelonephritis. J Am Geriatr Soc. 2009;57(11):2125–8.

Mnif MF, Kamoun M, Kacem FH, Bouaziz Z, Charfi N, Mnif F, et al. Complicated urinary tract infections associated with diabetes mellitus: pathogenesis, diagnosis and management. Indian J Endocrinol Metab. 2013;17(3):442–5.

Chen SL, Jackson SL, Boyko EJ. Diabetes mellitus and urinary tract infection: epidemiology, pathogenesis and proposed studies in animal models. J Urol. 2009;182(6):51–6.

Geerlings SE, Meiland R, van Lith EC, Brouwer EC, Gaastra W, Hoepelman AI. Adherence of type 1-fimbriated Escherichia coli to uroepithelial cells: more in diabetic women than in control subjects. Diabetes Care. 2002;25(8):1405–9.

Papadimitriou-Olivgeris M, Drougka E, Fligou F, Kolonitsiou F, Liakopoulos A, Dodou V, et al. Risk factors for enterococcal infection and colonization by vancomycin-resistant entero¬cocci in critically ill patients. Infection. 2014;42(6):1013–22.

Gorter KJ, Hak E, Zuithoff NP, Hoepelman AI, Rutten GE. Risk of recurrent acute lower urinary tract infections and prescription pattern of antibiotics in women with and without diabetes in primary care. Fam Pract. 2010;27(4):379–85.

Wilson ML, Gaido L. Laboratory diagnosis of urinary tract infections in adult patients. Clin Infect Dis. 2004;38:1150–8.

Patterson JE, Andriole VT. Bacterial urinary tract infections in diabetes. Infect Dis Clin North Am. 1995;9:25–51.

Wheat LJ. Infection and diabetes mellitus. Diabetes Care. 1980;3:187–97.

Janifer J, Geethalakshmi S, Satyavani K, Viswanathan V. Prevalence of lower urinary tract infection in South Indian type 2 diabetic subjects. Indian J Nephrol. 2009;19(3):107–11.

Geerlings SE, Meiland R, Hoepelman I M. Urinary tract infections in women with diabetes mellitus [Article in Dutch.] Ned Tijdschr Geneeskd. 2001;145(38):1832-6.

Bova JG, Potter JL, Arevalos E, Hopens T, Goldstein HM, Radwin HM. Renal and perirenal infection: to the role of computerized tomography. J Urol. 1985;133:375–8.

Goswami R, Bal CS, Tejaswi S, Punjabi GV, Kapil A, Kochupillai N. Prevalence of urinary tract infection and renal scars in patients with diabetes mellitus. Diab Res Clin Pract. 2001;53:181–6.

Geerlings SE, Meiland R, van Lith EC, Brouwer EC, Gaastra W, Hoepelman AI. Adherence of type 1-fimbriaeted E. coli to uro epithelial cells: Move in diabetic women than in control subjects. Diab Care. 2002;25:1405–9.

Geerlings SE, Stolk RP, Camps MJ, Netten PM, Collet TJ, Hoepelman AI. Risk factors for symptomatic urinary tract infection in women with diabetes. Diabetes Care. 2000;23(12):1737.