DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20190616

A study on prevalence of diabetes mellitus among adult tuberculosis patients in tertiary health care centre, Hyderabad

S.Bhavana Laxmi, Sri Harsha Kandikonda, Jyothi Lakshmi Naga Vemuri, R. L. Lakshman Rao

Abstract


Background: Tuberculosis is a major public health problem and is among top ten causes of deaths worldwide. People with diabetes are three times at higher risk of getting infected with tuberculosis. Globally 10.4 million TB cases exists of them 10% are linked to diabetes. In India 13% of Tuberculosis cases were diabetic. DM has been reported to modify the clinical features of TB. The objectives were to study the prevalence of diabetes mellitus among adult tuberculosis patients registered in DOTS centre in tertiary health care centre, Hyderabad and to study the clinical profile of tuberculosis in study subjects.

Methods: A cross sectional study was conducted in 4 DOTS centres under tertiary health care facility, Hyderabad. Sample size 200 was calculated using formula 4PQ/L2. Study subjects were registered adult tuberculosis patients attending DOTS centre and undergoing anti tuberculosis treatment. Data from study subjects was obtained by interview method using semi structured questionnaire consisting of socio-demographic parameters and clinical parameters.

Results: Out of 200 patients, the prevalence of DM was found to be 18% (n=36). Increasing age (p<0.000), male sex (p=0.04), low BMI (p=0.02), family history of TB (p=0.017), Sputum positive severity (p=0.0008) are significantly associated with DM-TB comorbidity and clinical manifestations like bilateral involvement (p=0.151), multi lobes (p=0.243), other associated lung diseases (p=0.154), treatment category (p=0.8203) are not significantly associated with DM-TB comorbidity.

Conclusions: Bidirectional screening of TB and DM will detect early and prevent complications of comorbiditiy.


Keywords


Prevalence, Tuberculosis, Diabetes

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References


National framework for joint TB-Diabetes collaborative activities March 2017; Central TB division; India, 2017.

Jeon CY, Murray MB. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med. 2008;5:152.

Stevenson CR, Critchley JA, Forouhi NG, Roglic G, Williams BG, Dye C, et al. Diabetes and the risk of tuberculosis: a neglected threat to public health? Chronic Illn. 2007;3:228–45.

Global Tuberculosis Report 2016. Geneva: World Health Organization; 2016.

Kumar A, Jain DC, Gupta D, Satyanarayana S, Kumar AM, Chadha SS, et al. Screening of patients with tuberculosis for diabetes mellitus in India. Trop Med Int Health. 2013;18:636-45.

Raghuraman S, Vasudevan KP, Govindarajan S, Chinnakali P, Panigrahi KC. Prevalence of Diabetes Mellitus among Tuberculosis Patients in Urban Puducherry. N Am J Med Sci. 2014;6(1):304.

Balakrishnan S, Vijayan S, Nair S, et al. High diabetes prevalence among tuberculosis cases in Kerala, India. PLoS One. 2012;7(10):e46502.

Olayinka AO, Anthonia O, Yetunde K. Prevalence of diabetes mellitus in persons with tuberculosis in a tertiary health centre in Lagos, Nigeria. Indian J Endocr Metab 2013;17:486-9.

Thapa B, Paudel R, Thapa P, Shrestha A, Poudyal AK. Prevalence of Diabetes among Tuberculosis Patients and Associated Risk Factors in Kathmandu Valley. Saarc J Tuber Lung Dis HIV/AIDS. 2015;12(2):20-7.

Ogbera AO, Kapur A, Abdur-Razzaq H, et al. Clinical profile of diabetes mellitus in tuberculosis. BMJ Open Diabetes Research and Care 2015;3:e000112.

Umakanth M, Rishikesavan S. Prevalence of diabetes mellitus among tuberculosis patient in Batticaloa district, Sri Lanka. Int J Med Res. 2017;2(2):21-3.