Serum 25-hydroxy vitamin D in asthmatic children and its relation to disease severity

Authors

  • Ihab Hafez El Sawy Department of Paediatrics, Faculty of Medicine, University of Alexandria, Egypt
  • Passant Al-Said Moaz Department of Clinical and Chemical Pathology, Faculty of Medicine, University of Alexandria, Egypt
  • Ghada Mohamed Farouk El Deriny Department of Paediatrics, Faculty of Medicine, University of Alexandria, Egypt
  • Mohamed Sami Abd El Moniem El Kholy Department of Paediatrics, Faculty of Medicine, University of Alexandria, Egypt

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20185510

Keywords:

Asthma, Vitamin D, Asthma severity, Children

Abstract

Background: Asthma is a chronic immunological disorder of the lungs. Vitamin D has several effects on the innate and adaptive immune systems. Little is known about vitamin D level and its impact on severity of asthma in children. This study aimed to determine vitamin D levels in asthmatics versus control children; studying the relation if any between these levels and asthma severity.

Methods: This cross-sectional study was conducted on 60 asthmatic children and 20 apparently healthy children as controls. Asthma patients were divided into 3 groups (mild, moderate, severe; 20 each). Asthma severity was based on GINA criteria. Vitamin D level was measured to all study group.

Results: The difference between the mean values of vitamin D level in control and asthmatic patients was statistically significant (p<0.001). This difference between control group and each asthma subgroup and between asthma subgroups versus each other were statistically significant being highest in control and lowest in patients with severe asthma (p<0.001). Differences in vitamin D status in control and all asthmatic patients were statistically significant (p<0.001). The difference between control group and each asthma subgroup according to vitamin D status were statistically significant (p<0.001). Concerning asthma subgroups the difference in vitamin D status between severe versus mild and moderate asthma were statistically significant (p<0.001), while between mild and moderate asthma it was not.

Conclusions: Significantly lower vitamin D level in asthmatic children compared to controls and a differential decrease in vitamin D levels in asthmatic children being lowest in severe asthma was confirmed.

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Published

2019-01-24

How to Cite

El Sawy, I. H., Moaz, P. A.-S., Farouk El Deriny, G. M., & Abd El Moniem El Kholy, M. S. (2019). Serum 25-hydroxy vitamin D in asthmatic children and its relation to disease severity. International Journal Of Community Medicine And Public Health, 6(2), 454–460. https://doi.org/10.18203/2394-6040.ijcmph20185510

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Original Research Articles