Correlation between pulmonary function tests and inflammatory markers in familial mediterranean fever patients
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20190165Keywords:
Familial mediterranean fever, Pulmonary function tests, Carbon monoxide diffusion analysesAbstract
Background: Familial mediterranean fever (FMF) is a disease frequently seen in some races and characterized by recurrent attacks affecting various organs with chronic inflammation. As a result of chronic inflammation, microvascular changes may occur. In this study, we aimed to investigate the association between pulmonary function tests and inflammatory markers in FMF patients.
Methods: Seventy-five FMF patients followed up at the Department of Internal Medicine who did not have any comorbidity affecting lung functions and 64 healthy subjects were enrolled. Both groups underwent CO (carbon monoxide) diffusion analysis and pulmonary function tests. Inflammatory markers of the groups were recorded as well and compared with CO diffusion and pulmonary function tests.
Results: FVC%, FEV1, FEV1%, FEV1/FVC, PEF, FEF25-75% values of the patient group was significantly lower than those in the control group. When compared, DLCO%, DLCO/VA, DLCO/VA% were also significantly lower than controls. There was a significant correlation between pulmonary function tests and ESR, hsCRP and fibrinogen levels.
Conclusions: Inflammation in FMF patients may lead to damage on pulmonary tissue that causes an impairment in pulmonary functions.
References
Medlej-Hashim M, Loiselet J, Lefranc G, Mégarbané A. Familial Mediterranean Fever (FMF): from diagnosis to treatment. Santé. 2004;14(4):261–6.
Brik R, Gershoni-Baruch R, Shinawi M, Barak L, Bentur L. Pulmonary manifestations and function tests in children genetically diagnosed with FMF. Pediatr Pulmonol. 2003;35(6):452-5.
Sahan C, Cengiz K. Pulmonary amyloidosis in familial Mediterranean fever Acta Clin Belg. 2006;61(3):147-51.
Lidar M, Pras M, Langevitz P, Livneh A. Thoracic and lung involvement in familial Mediterranean fever (FMF). Clin Chest Med. 2002;23(2):505-11.
Livneh A, Langevitz P, Pras M. Pulmonary associations in familial Mediterranean fever. Curr Opin Pulm Med. 1999;5(5):326-31.
Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115–26.
Koenig W, Sund M, Frohlich M, Fischer HG, Lowel H, Doring A, et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation. 1999;99(2):237–42.
Livneh A, Langevitz P. Diagnostic and treatment concerns in familial Mediterranean fever. Baillieres Best Pract Res Clin Rheumatol. 2000;14:477-98.
American Thoracic Society. Single-breath carbon monoxide diffusion capacity (transfer factor): recommendations for a standard technique. 1995 update. Am J Respir Crit Care Med. 1995;152:2185-8.
American Thoracic Society. Standardization of spirometry: 1994 update. Am J Respir Crit Care Med. 1995;152:1107-36.
Sinisalo J, Paronen J, Mattila KJ, Syrjälä M, Alfthan G, Palosuo T, et al. Relation of inflammation to vascular function in patients with coronary heart disease. Atherosclerosis. 2000;149:403–11.
Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135–43.
Paffen E, DeMaat MP. C-reactive protein in atherosclerosis: A causal factor? Cardiovasc Res. 2006;71(1):30-9.
Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, et al. Gas diffusion and alveolar–capillary unit in chronic heart failure. Eur Heart J. 2006;27(21):2538-43.
Caliskan M, Gullu H, Yilmaz S, Erdogan D, Unler GK, Ciftci O, et al. Impaired coronary microvascular function in familial Mediterranean fever. Atherosclerosis. 2007;195(2):161-7.
Caliskan Z, Gokturk HS, Caliskan M, Gullu H, Ciftci O, Ozgur GT, et al. Impaired coronary microvascular and left ventricular diastolic function in patients with inflammatory bowel disease. Microvasc Res. 2015;97:25-30.
Caliskan M, Erdogan D, Gullu H, Yilmaz S, Gursoy Y, Yildirir A, et al. Impaired coronary microvascular and left ventricular diastolic functions in patients with ankylosing spondylitis. Atherosclerosis. 2008;196(1):306-12
Kavukcu S, Türkmen M, Soylu A, Kasap B, Tatli Güneş B. Skin and muscle involvement as presenting symptoms in four children with familial Mediterranean fever. Clin Rheumatol. 2009;28(7):857-60
Brik R, Gershoni-Baruch R, Shinawi M, Barak L, Bentur L. Pulmonary manifestations and function tests in children genetically diagnosed with FMF. Pediatr Pulmonol. 2003;35(6):452-5.
