Quality of life among patients on MDR-TB treatment in a district tuberculosis centre of a metropolitan city

Authors

  • Apoorva E. Patel Department of Community Medicine, Akash Institute of Medical Sciences & Research Centre, Devanahalli, Bengaluru rural, India
  • K. Lalitha Department of Community Medicine, Ramaiah Medical College & Hospitals, Bengaluru, Karnataka, India
  • Dinesh Rajaram Department of Community Medicine, Ramaiah Medical College & Hospitals, Bengaluru, Karnataka, India
  • K. Radhika Department of Community Medicine, Ramaiah Medical College & Hospitals, Bengaluru, Karnataka, India
  • N. S. Murthy Department of Community Medicine, Ramaiah Medical College & Hospitals, Bengaluru, Karnataka, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20184816

Keywords:

MDR-TB, Quality of Life, BBMP, Bengaluru, QOL

Abstract

Background: MDRTB is a global health concern with its current prevalence in India being 2.3% and 17.2% respectively among newly diagnosed and previously treated cases. Besides its clinical impact, the disease affects the QOL of patients suffering from MDR-TB. The objective of the study was to assess the quality of life among MDR-TB cases in comparison with non-MDR TB cases and TB cured subjects (Category I, RNTCP).

Methods: A cross sectional study was conducted in all the 14 TUs under District Tuberculosis Centre of Municipal Corporation of Bengaluru (BBMP). Study subjects comprised of 52 MDR-TB Cases, 53 Non-MDR-TB cases and 54 Category I TB cured subjects. WHOQOL BREF questionnaire was used to assess the QOL among study subjects. Median [IQR] scores of QOL in each of the domains among various groups were compared using Kruskal Wallis test. P<0.05 was considered as statistically significant.

Results: Median age among MDRTB cases was 35 years [IQR: 26-50] whereas it was 37 years [IQR: 28-47] among Non MDRTB cases and 30.5 years [IQR: 22-45] among TB cured subjects. Out of 52 MDRTB cases, 26(50%) were females compared to 14 (26.4%) among Non MDRTB cases and 26(48.1%) among TB cured subjects (p=0.0024). As compared to non MDRTB cases, physical and environmental domains’ scores of MDRTB cases were significantly low (p=0.01 and p=0.001 respectively).Whereas, as compared to TB cured subjects, physical and psychological domains’ scores of MDRTB cases were significantly low (p<0.001 and p<0.001 respectively).

Conclusions: The QOL of patients suffering from TB is affected and the impact is even worse in MDRTB. Hence prompt treatment of TB and early diagnosis of MDRTB will reduce the disease severity and improve the QOL.

Author Biographies

Apoorva E. Patel, Department of Community Medicine, Akash Institute of Medical Sciences & Research Centre, Devanahalli, Bengaluru rural, India

Assistant Professor, Dept. of Community Medicine

K. Lalitha, Department of Community Medicine, Ramaiah Medical College & Hospitals, Bengaluru, Karnataka, India

Professor

Dinesh Rajaram, Department of Community Medicine, Ramaiah Medical College & Hospitals, Bengaluru, Karnataka, India

Associate Professor, Dept. of Community Medicine

K. Radhika, Department of Community Medicine, Ramaiah Medical College & Hospitals, Bengaluru, Karnataka, India

Lecturer cun Statistician

N. S. Murthy, Department of Community Medicine, Ramaiah Medical College & Hospitals, Bengaluru, Karnataka, India

Research Co-Ordinator, Division of Research and Patents

 

References

WHO. Tuberculosis factsheets. WHO. Available at: http://www.who.int/mediacentre/factsheets/fs104/en/. Accessed on 28 March 2016.

WHO. Global tuberculosis report 2015. WHO. Available at: http://www.who.int/tb/publications/ global_report/en/. Accessed on 28 March 2016.

DOTS Plus Guidelines 2010. Cent TB Div Dir Gen Health Serv Health Fam Welf Govt India. Available at: health.bih.nic.in/Docs/Guidelines/ Guidelines-DOTS-Plus.pdf. Accessed on 28 March 2016.

Dhuria M, Sharma N, Ingle G. Impact of Tuberculosis on the Quality of Life. Indian J Community Med. 2008;33(1):58–9.

WHO. WHOQOL User Manual: Prgramme on Mental Health. Available at: www.who.int/mental_ health/evidence/who_qol_user_manual_98.pdf. Accessed on 11 March 2016.

Sharma R, Yadav R, Sharma M, Saini V, Koushal V. Quality of life of multi drug resistant tuberculosis patients: a study of north India. Acta Med Iran. 2014;52(6):448–53.

Aggarwal AN. Health-related quality of life: A neglected aspect of pulmonary tuberculosis. Lung India. 2010;27(1):1–3.

Kakhki AD, Masjedi MR. Factors Associated with Health-Related Quality of Life in Tuberculosis Patients Referred to the National Research Institute of Tuberculosis and Lung Disease in Tehran. Tuberc Respir Dis. 2015;78(4):309–14.

Chamla D. Chamla D. The assessment of patients’ health-related quality of life during tuberculosis treatment in Wuhan, China. Int J Tuberc Lung Dis. 2004;8(9):1100–6.

Ayub T, Nazir U, Sideeq K. Quality Of Life of Multi Drug Resistant Tuberculosis Cases of Kashmir Valley. IJIRMS. 2017;02(08):1113-7.

Dhiman S, Bansal R, Kansal D, Sharma PK. Assessment of health related quality of life of drug resistant Tuberculosis patients. India J Pharmacy Pharmacol. 2018;5(2):62-5.

Qahtani MFA, Mahalli AA, Dossary NA,, Muhaish AA, Otaibi SA, Baker FA. Health-related quality of life of tuberculosis patients in the Eastern Province, Saudi Arabia. J Taibah Univ Med Sci. 2014;9(4):311–7.

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Published

2018-11-24

How to Cite

Patel, A. E., Lalitha, K., Rajaram, D., Radhika, K., & Murthy, N. S. (2018). Quality of life among patients on MDR-TB treatment in a district tuberculosis centre of a metropolitan city. International Journal Of Community Medicine And Public Health, 5(12), 5355–5359. https://doi.org/10.18203/2394-6040.ijcmph20184816

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Section

Original Research Articles