Effects of diabetes mellitus on gallbladder

Bandar Alshalawi, Abdullah Almuslam, Reem Alqahtani, Al-Hanuf Al-Bokhari, Wed Alnajjar, Amani Alsafi, Rehab Almajnooni, Firas Hasaballah, Nof Alqarni, Mutlaq Alsolami


Diabetes has been theorized to build the danger of gallbladder complaint in light of the perception that insulin resistance and obesity are related with gallbladder. We conducted this meta-analysis using a comprehensive search of MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials till 15 January 2017 for prospective observational studies that assessed the relationship of the effects of diabetes mellitus on gallbladder. We identified 8 prospective studies that could be included in the meta-analysis which included 6,089,807 participants. The summary RR for diabetes patients was 1.42 (95% CI: 1.32–1.87, I2=99.4%, p<0.0001). Although heterogeneity in general was very high, there was no heterogeneity between the studies with longer duration of follow-up. There was no evidence of publication bias. Our study shows additional support for an increased risk of gallbladder disease between diabetes patients.


Gallstones, Gallbladder disease, Diabetes mellitus

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