A study of treatment outcome of paediatric tuberculosis patients in an urban city of central India

Sheloj Joshi


Background: It is an established fact that healthy children build healthy nation. Proper management of Paediatric Tuberculosis is very essential for the control of tuberculosis as children also act as a source of infection within a community. The objective of the study was to determine the treatment outcome of paediatric TB patients registered under RNTCP in Bhopal city and to determine the relationship of socio-demographic profile and other selected factors with treatment outcome in Paediatric TB patients registered under RNTCP in Bhopal city.

Methods: In this longitudinal study, data of all the paediatric TB patients (0 to 14 years of age group) diagnosed as TB and registered under R.N.T.C.P and fulfilling inclusion criteria during January 2013 to June 2013 were collected after obtaining informed consent from parents/guardians by using a structured questionnaire during their visit to designated microscopic centre (DMC) cum DOTS centre. The data was analysed on statistical software SPSS VS.20.

Results: In our study 93.33% of paediatric patients were treatment completed, 4.84% were declared cure and 0.60% patients each were transferred out, declared treatment failure and died respectively. Educational status of mothers of paediatric patients (X2=40.569 and p=0.019, df=24), BCG vaccination (X2=11.299 and p=0.023, df=4) and nutritional status of children (X2=26.342 and p=0.049, df=16) are significantly associated with treatment outcome.

Conclusions: Majority of paediatric patients were declared cured or treatment completed depending upon the result of sputum examination. In our study educational status of mothers of paediatric patients, BCG vaccination and nutritional status of children are significantly associated with treatment outcome. No association of treatment outcome was found with other selected factors such as age, gender, religion, type of family and socio economic status of paediatric patients.


Paediatric tuberculosis, RNTCP, Treatment outcome

Full Text:



Amdekar YK. Consensus Statement on Childhood Tuberculosis. Indian Pediatrics 2010;47(1):41-55.

Satyanarayana S, Shivashankar R, Vashist RP, Chauhan LS, Chadha SS, Dewan PK, et al. Characteristics and Programme-Defined Treatment Outcomes among Childhood Tuberculosis (TB) Patients under the National TB Programme in Delhi. PLOS ONE. 2010;5(10):e13338.

Kabra SK, Lodha R, Seth V. Category-based Treatment of TB in Children. Indian Paediatr. 2004;41:927-37.

Sharma S, Sarin R. The DOTS strategy for treatment of Paediatric Pulmonary Tuberculosis in South Delhi, India. Int J Tuberc Lung Dis. 2008;12:74-80.

Sivanandan S, Walia M, Lodha R, Kabra K. Factors Associated with Treatment Failure in Childhood TB. Indian Paediatr. 2008;45:769-71.

Indumathi CK, Prasanna KK, Dinakar C, Shet A, Lewin S. Intermittent Short Course Therapy for Paediatric Tuberculosis. Indian Paediatr. 2010;47:93-6.

Sharma S, Sarin R. Clinical profile and treatment outcome of Tuberculous Lymphadenitis in children using DOTS strategy. Indian J Tuberc. 2010;57:4-11.

Ruchi, Thakur HP. Characteristics of Childhood Tuberculosis Patients Registered under RNTCP in Varanasi, Uttar Pradesh. Indian J Public Health. 2013;57(1):36-9.

Puwar B, Patel V, Puwar T. A Record Based Study on Paediatric Tuberculosis in Ahmedabad City, India. National J Community Med. 2012;3(1):153-6.

Ramesh, Shobha A, Manjula VD. Treatment Outcomes of Childhood Tuberculosis with Dots Strategy in Kottayam, Kerela. Indian J Community Health. 2012;24(4):280-4.

Nelliyanil M, Sharada MP, Joseph N, Basagoudar SS, Jayaram S, Patil DC. A Study of the Socio-Demographic Profile and Treatment Outcome of Paediatric Tuberculosis Patients in Bangalore Mahanagar Palike Area. Indian J Tuberc. 2012;59:207-13.

Hailu D, Abegaz WE, Belay M. Childhood tuberculosis and its treatment outcomes in Addis Ababa: a 5-years retrospective study. BMC Pediatr. 2014;14:61.

Mukherjee A, Chowdhury R, Singla R, Saha I, Dutta R, Das T. Comparison between childhood and adult tuberculosis in a rural tuberculosis unit of West Bengal: A retrospective study. Lung India. 2014;3(2):116-20.

Ordway D, Harton M, Henao-Tamayo M, Montoya R, Orme IM, Gonzalez-Juarrero M. Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis. J Immunol. 2006;176:4931-9.

Djibuti M, Mirvelashvili E, Makharashvili N, Magee MJ. Household income and poor treatment outcome among patients with tuberculosis in Georgia: a cohort study. BMC Public Health. 2014;14:88.