Risk of pancreatic cancer in Minia district, Egypt

Authors

  • Marwa G. Abdelrehim Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA
  • Eman M. Mahfouz Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt
  • Ashraf A. Ewis Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt
  • Amany E. Seedhom Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt
  • Hassan M. Afifi Department of Surgical Oncology, Minia Cancer Center, Minia, Egypt
  • Fatma M. Shebl Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20175760

Keywords:

Pancreatic cancer, Risk factors, Minia Cancer Center, Egypt

Abstract

Background: Pancreatic cancer is considered one of the most lethal malignant neoplasms. Therefore, a better understanding of the etiology and identifying the risk factors are essential for the development of preventive strategies.

Methods: This case-control study included pancreatic cancer patients attending Minia Cancer Center during the period from June 2014 to December 2015 and controls from the general population. Several suspected risk factors were evaluated during personal interviews with the study participants. Statistical analysis included crude odds ratio (OR) and multivariable logistic regression with an adjusted OR and 95% confidence interval (CI).

Results: The study included 224 subjects, 75 pancreatic cancer cases, and 149 controls. Cases had higher age and male gender than controls. Bivariate analyses showed that age, sex, smoking, family history of pancreatic cancer, physical activity, mental stress, age at first birth, hormonal contraception, diabetes, hepatitis C virus (HCV) infection, pancreatitis, and cholecystitis were associated with pancreatic cancer. In the final multivariable analysis, smoking, physical activity, diabetes, HCV infection, and cholecystitis were significantly associated with pancreatic cancer risk.

Conclusions: Pancreatic cancer risk is associated with some potentially modifiable factors like tobacco smoking and low physical activity and related health problems as diabetes, HCV infection, and cholecystitis. Control of known risk factors for pancreatic cancer should be considered to help in risk reduction and prevention.

 

Author Biographies

Marwa G. Abdelrehim, Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA

Department of Public Health and Preventive Medicine, Faculty of Medicine

Eman M. Mahfouz, Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt

Department of Public Health and Preventive Medicine, Faculty of Medicine

Ashraf A. Ewis, Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt

Department of Public Health and Preventive Medicine, Faculty of Medicine

Amany E. Seedhom, Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt

Department of Public Health and Preventive Medicine, Faculty of Medicine

Fatma M. Shebl, Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA

Yale School of Public Health, Chronic Disease Epidemiology Department

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Published

2017-12-23

How to Cite

Abdelrehim, M. G., Mahfouz, E. M., Ewis, A. A., Seedhom, A. E., Afifi, H. M., & Shebl, F. M. (2017). Risk of pancreatic cancer in Minia district, Egypt. International Journal Of Community Medicine And Public Health, 5(1), 38–46. https://doi.org/10.18203/2394-6040.ijcmph20175760

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Original Research Articles