DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20163065

The prevalence and clinical profile of dry eye in tertiary hospital based normal healthy population in Uttarakhand, India

Pooja Baisoya, Anuradha Raj, Harsh Bahadur, R. C. Nagpal

Abstract


Background: Dry eye  is  a  multifactorial  disorder  of the  tear  film  due  to  lack of tears or its excessive  evaporation  which  can potentially  damage  the  ocular surface  and  is  associated  with symptoms of ocular discomfort  as defined by  the  National  Eye Institute (NEI)  Industry  workshop  in  1995. Objective of the study was to study the prevalence and the clinical profile of dry eye in hospital-based normal healthy population.

Methods: In this observational study, 503 patients were screened for dry eye on the basis of questionnaire adopted from Dry Eye Workshop questionnaire which included five symptoms. On the basis of two or more than two symptoms, patients were divided into two groups Group I and Group II respectively. All patients underwent routine ophthalmological examination along with evaluation of tear parameters like Schirmer's test I, tear film break-up time, slit lamp assisted tear meniscus height measurement, Rose Bengal staining and tear film thinning time. On the basis of questionnaire and tear parameters, 235 patients were found eligible for the study. Final grading of dry eye into four grades was done according to Dry Eye Workshop. Severity of dry eye was divided into three grades as mild, moderate and severe with total score of <3, 3-4, >4 respectively. The data was analysed by using Pearson’s correlation of coefficient and multiple comparison tests with SPSS 22 version. P value<0.05 was taken statistically significant.

Results: The prevalence of dry eye in our study was found to be 46.71%. Mean age of the patients was 47.80±16.37 years. Mild, moderate and severe dry eye was seen in 136 (57.87%), 92 (39.14%) and 3 (1.27%) patients respectively. Mean standard value of Schirmer’s test I , tear film break-up time, tear meniscus height and tear film thinning time were 13.59±6.65, 9.66±2.45, 0.39±0.15 and 10.15±2.24 respectively. The P values of all tear parameters were 0.001 which were statistically significant.

Conclusions: Dry eye disease prevales to greater extent even in asymptomatic healthy patients and its reliable diagnosis can be done on the basis of both symptoms and tear parameters. Screening of symptomatic patients without any sign of dry eye in the preclinical phase is important for its early detection.


Keywords


Dry eye, Tear film break-up time, Schirmer′s test I, Dry eye questionnaire

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References


Lemp MA. Report of the National Eye Institute/Industry Workshop on clinical trials in dry eyes. CLAO J. 1995;21:221-32.

Anderson JA, Whaley K, Williamson J, Buchanan WW. A statistical aid to the diagnosis of keratoconjuctivitis sicca. Q J Med, New Series. 1972;41:175-89.

DEWS Definition and classification. The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of International Dry Eye Workshop. Ocul Surf. 2007;5:75-92.

The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye Workshop 2007. Ocul Surf. 2007;5;93-107.

Sahai A, Malik P. Dry eye: prevalence and attributable risk factors in a hospital-based population. Indian J Ophthalmol. 2005;53:87-91.

Brewitt H, Sistani F. Dry eye disease: the scale of the problem. Surv Ophthalmol. 2001;45:199-202.

Tseng SCG. Topical tretinoin treatment for dry eye disorders. In: Smolin G and Friedianender MH. eds. The dry eye. Int Ophthalmol Clin. 1987;27(1):47-53.

Schein OD, Tielsch JM, Munoz B, Bandeen-Roche K, West S. Relation between signs and symptoms of dry eye in the elderly. A population –based perspective. Ophthalmology. 1997;104:1395-401.

Gupta N, Prasad I, Jain R, D’Souza P. Estimating the prevalence of dry eye among Indian patients attending a tertiary ophthalmology clinic. Ann Trop Med Parasitol. 2010;104:247-55.

Onwubiko SN, Eze BI, Udeh NN, Arinze OC, Onwasigwe EN, Umeh RE. Dry eye disease prevalence distribution and determinants in a hospital based population. Cont Lens Anterior Eye. 2014;37(3):157-61.

Bhatnagar KR, Sapovadia A, Gupta D, Kumar P, Jasani H. Dry eye syndrome: A rising occupational hazard in tropical countries. Med J DY Patil Univ. 2014;7:138.

Jie Y, Xu L, Wu YY, Jonas JB. Prevalence of dry eye among adult Chinese in the Beijing Eye Study. Eye. 2009;23:688-93.

Wang J, Palakuru JR, Aquavella JV. Correlations among upper and lower tear menisci, non-invasive tear break-up time and Schirmer's test. Am J Ophthalmol. 2008;145(5):795-800.

Ibrahim OM, Dogru M, Takano Y, Satake Y, Wakamatsu TH, Fukagawa K, et al. Application of Visante optical coherence tomography tear meniscus height measurement in the diagnosis of dry disease. Ophthalmology. 2010;117:1923-9.

Li J, Shen M, Wang J, Ma H, Tao A, Xu S, et al. Clinical significance of tear menisci in dry eye. Eye Contact Lens. 2012;38(3):183-7.

Cynthia IT, Andrew FP, Koray G, Stephen CP. Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters. Am J Ophthalmol. 2014;157:301-10.