Relations of body weight status in early adulthood and weight changes until middle age with metabolic syndrome in the Chinese population

Authors

  • Liancheng Zhao State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • Huanhuan Liu State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • Long Zhou State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • Ying Li State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • Min Guo State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • Yangfeng Wu Peking University Clinical Research Institute, Beijing, China

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20174810

Keywords:

Body mass index, Weight change, Metabolic syndrome

Abstract

Background: The evidences for the relationship between long-term weight gain and metabolic syndrome (MetS) in Chinese population were limited. Therefore, this study aims to explore the association of body weight status in early adulthood and weight changes with MetS.

Methods: Data from China Multicenter Collaborative Study of Cardiovascular Epidemiology including 12808 participants aged 35–59 were used. Participants were surveyed for cardiovascular risk factors and a self-reported weight at age 25, which was defined as early adulthood. Weight change was calculated as the difference between baseline weight and early adulthood weight. MetS was defined according to AHA/NHLBI definition in 2009. Multivariate logistic regression model was used to examine the association between early adulthood weight status, weight change and MetS.

Results: Mean age of participants was 46.7 years, including 6134 men and 6674 women. The overall prevalence of MetS was 21.8%. After adjusted for age, sex and other confounding factors, both BMI at 25 age and weight gain were positively associated with the risk of MetS. Being overweight (BMI, 24–27.9 kg m-2) or obese (BMI ≥28 kg m-2) at early adulthood was related to an increased risk of MetS, the odds ratio (OR) and 95%confidence interval (CI) was 3.24 (2.82–3.72) and 13.31 (8.72–20.31). In addition, weight gain was also associated with higher risk of MetS (P for trend<0.01).

Conclusions: Overweight and obesity in early adulthood and weight gain were both independently related to an increased risk of MetS in the middle-aged Chinese men and women. 

References

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143-421.

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735-52.

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640-5.

Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol. 2007;49(4):403-14.

Malik S, Wong ND, Franklin SS, Kamath TV, L'Italien GJ, Pio JR, et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation. 2004;110(10):1245-50.

Bradshaw PT, Monda KL, Stevens J. Metabolic syndrome in healthy obese, overweight, and normal weight individuals: the Atherosclerosis Risk in Communities Study. Obesity (Silver Spring). 2013;21(1):203-9.

Ford ES, Giles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among U.S. Adults. Diabetes Care. 2004;27(10):2444-9.

Mi YJ, Zhang B, Wang HJ, Yan J, Han W, Zhao J, et al. Prevalence and Secular Trends in Obesity Among Chinese Adults, 1991-2011. Am J Prev Med. 2015;49(5):661-9.

Carnethon MR, Loria CM, Hill JO, Sidney S, Savage PJ, Liu K. Risk factors for the metabolic syndrome: the Coronary Artery Risk Development in Young Adults (CARDIA) study, 1985-2001. Diabetes Care. 2004;27(11):2707-15.

Bot M, Spijkerman AM, Twisk JW, Verschuren WM. Weight change over five-year periods and number of components of the metabolic syndrome in a Dutch cohort. Eur J Epidemiol. 2010;25(2):125-33.

Suzuki A, Akamatsu R. Long-term weight gain is related to risk of metabolic syndrome even in the non-obese. Diabetes Metab Syndr. 2014;8(3):177-83.

Zhang LF, Yang J, Hong Z, Yuan GG, Zhou BF, Zhao LC, et al. Proportion of different subtypes of stroke in China. Stroke. 2003;34(9):2091-6.

Zhou B, Wu Y, Yang J, Li Y, Zhang H, Zhao L. Overweight is an independent risk factor for cardiovascular disease in Chinese populations. Obes Rev. 2002;3(3):147-56.

Zhou BF. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002;15(1):83-96.

Alley DE, Chang VW. Metabolic syndrome and weight gain in adulthood. J Gerontol A Biol Sci Med Sci. 2010;65(1):111-7.

Lloyd-Jones DM, Liu K, Colangelo LA, Yan LL, Klein L, Loria CM, et al. Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Circulation. 2007;115(8):1004-11.

Nooyens AC, Visscher TL, Verschuren WM, Schuit AJ, Boshuizen HC, van Mechelen W, et al. Age, period and cohort effects on body weight and body mass index in adults: The Doetinchem Cohort Study. Public Health Nutr. 2009;12(6):862-70.

Perry GS, Byers TE, Mokdad AH, Serdula MK, Williamson DF. The validity of self-reports of past body weights by U.S. adults. Epidemiology. 1995;6(1):61-6.

Tamakoshi K, Yatsuya H, Kondo T, Hirano T, Hori Y, Yoshida T, et al. The accuracy of long-term recall of past body weight in Japanese adult men. Int J Obes Relat Metab Disord. 2003;27(2):247-52.

Schlichting P, Hoilund-Carlsen PF, Quaade F. Comparison of self-reported height and weight with controlled height and weight in women and men. Int J Obes. 1981;5(1):67-76.

Downloads

Published

2017-10-25

How to Cite

Zhao, L., Liu, H., Zhou, L., Li, Y., Guo, M., & Wu, Y. (2017). Relations of body weight status in early adulthood and weight changes until middle age with metabolic syndrome in the Chinese population. International Journal Of Community Medicine And Public Health, 4(11), 4011–4017. https://doi.org/10.18203/2394-6040.ijcmph20174810

Issue

Section

Original Research Articles