Clinical and haematological parameters associated with patients of visceral leishmaniasis in a district of North Bihar
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20172156Keywords:
Visceral leishmaniasis, Fever, HaematologicalAbstract
Background: Visceral leishmaniasis is highly endemic in West Champaran district of Bihar. This endemicity is supposed to be due to poor hygiene and sanitation and poor control of vectors. This study was done to study clinical and haematological parameters of Kala-azar patients in this area.
Methods: A retrospective data collection was done in a medical college of north Bihar. Study duration was one year from January 2016 to December 2016. 43 cases, rk-39 positive from 13 blocks of W. Champaran admitted at medical college were studied for clinical and haematological parameters.
Results: Bhitha was the highest affected block (25.58%) followed by Manjhaulia (23.25%) Fever was the commonest presentation whereas splenomegaly was the most common sign. Pallor was seen in 90 % cases and hepatomegaly in 60 % cases. Patients presented with bleeding manifestation in 9.3% cases and lymphadenopathy in 6.9% cases. Among blood parameters anaemia was seen in 93% cases and thrombocytopenia in 83%. Microcytic hypochromic blood picture was the most common peripheral blood picture.
Conclusions: Extensive epidemiological investigation is needed to find out hidden cases in this area.
References
Leishmaniasis Fact sheet N°375. World Health Organization, 2014. Available at http://www.who.int/leishmaniasis/en/. Accessed on 17 February 2014.
Mauricio IL, Stothard JR, Miles MA. The strange case of Leishmania chagasi. Parasitol Today. 2000;16:188–90.
Alvar J, Vélez ID, Bern C, Herrero M, Desjeux P, Cano J, et al. Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE. 2012;7(5):35671.
Perry D, Dixon K, Garlapati R, Gendernalik A, Poche D, Poche R. Visceral Leishmaniasis Prevalence and Associated Risk Factors in the Saran District of Bihar, India, from 2009 to July of 2011. Am J Trop Med Hygiene. 2013;88(4):778–84.
Bern C, Chowdhury R. The epidemiology of visceral leishmaniasis in Bangladesh: prospects for improved control. Indian J Med Res. 2006;123(3):275-88.
Joshi A, Narain JP, Prasittisuk C, Bhatia R, Hashim G, Jorge A, et al. Can visceral leishmaniasis be eliminated from Asia? J Vector Borne Dis. 2008;45(2):105-11.
A consultation meeting on indicators for Kala-azar elimination organized at SEARO office, New-Delhi in June 09.
Brain storming session meeting at National Vector Borne Diseases Control Programme office, NewDelhi on 19th Jan. 2011.
Dhingra KK, Gupta P, Saroha V, Setia N, Khurrana N, Singh T. Morphological findings in bone marrow biopsy and aspirate smears of visceral Kala azar: A review. Indian J Pathol Microbiol. 2010;53(1):96-100.
Agarwal Y, Sinha AK, Upadhyaya P, Kafle SU, Rijal S, Khanal B. Haematological Profile in visceral leishmaniasis. Int J Infect Microbiol. 2013;2(2):39-44.
Shoaib A, Wajiha R, Ali I, Zafar Z, Sumaira Z, Khalid F, Awan MU. Visceral leishmaniasis- A study of 42 cases. Ann Pak Inst Med Sci. 2009;5(3):151-3.
Chakrabarti S, Sarkar S, Goswami BK, Sarkar N, Das S. Clinico- haematological Profile of visceral leishmaniasis in immunocompetent patients. Southeast Asian J Trop Med Public Health. 2013;44(2):143-9.
Hamid GA, Gobah GA. Clinical and haematological manifestations of visceralleishmaniasis in Yemeni children. Turk J Haematol. 2009;26(1):25-8.
Varma N, Naseem S. Haematologic changes in visceral leishmanisis/ Kala Azar. Indian J Haematol Blood Transfus. 2010;26(3):78–82.
Jain A, Naniwadekar M. An etilogical reappraisal of pancytopenia-largest case series reported to date from a single tertiary care teaching hospital. BMC Haematology. 2013;13:10