Factors affecting survival of women with breast cancer in King Fahad Medical City, Saudi Arabia
DOI:
https://doi.org/10.18203/2394-6040.ijcmph20171306Keywords:
Breast Cancer, Female, Survival, PrognosisAbstract
Background: Breast cancer is the most frequently diagnosed cancer among women in 140 of 184 countries worldwide. The association between breast cancer survival and socio-demographic and pathologic factors has been widely studied in the developed countries. But scarce data is available from Saudi Arabia. We aimed to determine the overall observed one year and three years survival rate of female breast cancer patients and to investigate the factors affecting survival rate.
Methods: Retrospective data was collected from the cancer center registry at King Fahad Medical City (KFMC) that included all women diagnosed with breast cancer between 1st January 2011 till 31st December 2012 and were followed to 31st December 2015 (cut off point for follow-up). Kaplan-Meier analysis was done to assess overall survival. The factors affecting survival rate such as age, histological type, tumor grade at diagnosis, metastases and treatment options were investigated using log rank test and Cox regression analysis.
Results: The overall observed survival probability of the study population at 1, and 3 years was 95%, and 85%, respectively. The 3 year survivals for the younger (≤40 years), 41-50 years and older (50+ years) patients were 83.9%, 90.6% and 80.6% respectively, the differences not reaching statistical significance. There were statistically significant associations between three year survival and histological type of tumour, laterality, metastases and type of treatment by the univariate analysis log rank test.
Conclusions: One and three-year survival rate of breast cancer at KFMC was 96% and 85% respectively. Investigating the factors affecting survival rate is one of the most essential means of improving cancer prognosis.
References
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. Lyon, France: International Agency for Research on Cancer, 2013. Available at http://globocan.iarc.fr. Accessed 26 October 2016.
Saggu S, Rehman H, Abbas ZK, Ansari AA. Recent incidence and descriptive epidemiological survey of breast cancer in Saudi Arabia. Saudi Med J. 2015;36(10):1176.
El Saghir NS, Khalil MK, Eid T, El Kinge AR, Charafeddine M, Geara F, et al. Trends in epidemiology and management of breast cancer in developing Arab countries: a literature and registry analysis. Int J Surg. 2007;5(4):225-33.
Kumar S, Burney IA, Al-Ajmi A, Al-Moundhri MS. Changing trends of breast cancer survival in sultanate of oman. Journal of Oncology. 2011(2011):1-7. Article ID 316243.
Coleman MP, Quaresma M, Berrino F, Lutz J, De Angelis R, Capocaccia R, et al. Cancer survival in five continents: a worldwide population-based study (CONCORD). The lancet oncology. 2008;9(8):730-56.
Compton CC, Byrd DR, Garcia-Aguitar J, Kurtzman SH, Olawaiye A, Washington NK. AJCC Cancer Staging Atlas: A Companion to the Seventh Editions of the AJCC Cancer Staging Manual and Handbook; 2012.
Ravichandran K, Hamdan N, Dyab A. Population based survival of female breast cancer cases in Riyadh Region, Saudi Arabia. Asian Pac J Cancer Prev. 2005;6(1):72-6.
Ziaei JE, Sanaat Z, Asvadi I, Dastgiri S, Pourzand A, Vaez J. Survival analysis of breast cancer patients in Northwest Iran. Asian Pac J Cancer Prev. 2013;14(1):39-42.
Cancer Research UK, Cancer Survival group, London School of Hygeine and Tropical Medicine; 2014.
Zhu J, Chen JG, Chen YS, Zhang YH, Ding LL, Chen TY. Female breast cancer survival in Qidong, China, 1972–2011: a population-based study. BMC Cancer. 2014;14:318.
Sathwara J, Bobdey S, Ganesh B. Breast Cancer Survival Studies in India: a review. Int J Res Med Sci. 2016;4(8):3102-8.
Graeser MK, Engel C, Rhiem K, Gadzicki D, Bick U, Kast K, et al. Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers. J Clin Oncol. 2009;27(35):5887-92.
Kwan ML, Kushi LH, Weltzien E, Tam EK, Castillo A, Sweeney C, et al. Alcohol consumption and breast cancer recurrence and survival among women with early-stage breast cancer: the life after cancer epidemiology study. J Clin Oncol. 2010;28(29):4410-6.
Protani M, Coory M, Martin JH. Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast cancer Res Treat. 2010;123(3):627-35.
Peairs KS, Barone BB, Snyder CF,Yeh HC, Stein KB, Derr RL, et al. Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis. J Clin Oncol. 2011;29(1):40-6.
Sprague BL, Trentham Dietz A, Gangnon RE, Ramchandani R, Hampton JM, Robert SA, et al. Socioeconomic status and survival after an invasive breast cancer diagnosis. Cancer. 2011;117(7):1542-51.
American Cancer Society (ACS). Cancer Facts and Figures, 2013. Available at http://www.cancer.gov/ research/cancerfactsstatistics/breast-cancer-facts-figures. Accessed 27 October 2016.
Khan H, Saxena A, Gabbidon K, Stewart T, Bhatt C. Survival analysis for white non-Hispanic female breast cancer patients. Asian Pac J Cancer Prev. 2013;15(9):4049-54.
Tarawneh M, Arqoub K, Sharkas G. Epidemiology and survival analysis of Jordanian female breast cancer patients diagnosed from 1997 to 2002. Middle East J Cancer. 2011;2(2):71-80.
Brandt J, Garne JP, Tengrup I, Manjer J. Age at diagnosis in relation to survival following breast cancer: a cohort study. World J Surg Oncol. 2015;13(1):1.
Gnerlich J, Deshpande A, Jeffe D, Sweet A, White N, Margenthaler J. Elevated breast cancer mortality in young women (<40 yrs) compared with older women is attributed to poorer survival in early stage disease. American College of Surgeons Clinical Congress, 2008.
Margenthaler J. Younger women diagnosed with early-stage breast cancer more likely to die than older women. American College of Surgeons Clinical Congress, 2008.
Tristan R, Sylvain L, Sophie B, Juliette P, Maylis D, Mathieu N. Predictive Factors of the Survival of Women With Invasive Breast Cancer in French Guiana: The Burden of Health Inequalities. Clin Breast Cancer. 2016;16(4):e113–8.
Simpson JF, Gray R, Dressler LG. Prognostic value of histologic grade and proliferative activity in axillary node-positive breast cancer: results from the Eastern Cooperative Oncology Group Companion Study, EST 4189. J Clin Oncol. 2000;18(10):2059-69.
Rosen PP, Groshen S, Kinne DW. Prognosis in T2N0M0 stage I breast carcinoma: a 20-year follow-up study. J Clin Oncol. 1991;9(9):1650-61.
Diab SG, Clark GM, Osborne CK, Libby A, Allred DC, Elledge RM. Tumor characteristics and clinical outcome of tubular and mucinous breast carcinomas. J Clin Oncol. 1999;17(5):1442-8.
Rakha EA, Lee AH, Evans AJ, Menon S, Assad NY, Hodi Z, et al. Tubular carcinoma of the breast: further evidence to support its excellent prognosis. J Clin Oncol. 2010;28(1):99-104.
