DOI: https://dx.doi.org/10.18203/2394-6040.ijcmph20222918
Published: 2022-10-29

A community based prospective study on thyroid dysfunction among pregnant females and its effect on maternal and neonatal outcome

Srishti Kukreja, Shakila Mulla, Subhashree Das, Lakhan Singh

Abstract


Background: Thyroid disorders are often overlooked in pregnancy because of their non-specific symptoms and the hypermetabolic state of pregnancy. The laboratory measurements of thyroid function play an important role in the assessment of maternal thyroid health. Thyroid disorders can have grievous effect on mother and new-borne which can be prevented. The study was aimed to find the prevalence of thyroid dysfunction among pregnant females and its effect on maternal and neonatal outcome.

Methods: A prospective study was conducted from August 2019 to October 2020 among 360 pregnant females in the rural fields practice area of a medical college. Thyroid function test was done in all pregnant females and the maternal and neonatal outcome was noted.

Results: 20.31% of the pregnant females were found to be suffering from thyroid dysfunction which is approximately 1/5th of the total sample. Out the total females with thyroid dysfunction maximum females suffered from subclinical hypothyroidism that is 10.94% while 1.56% had overt hypothyroidism. 1.88% and 5.94% had subclinical and overt hyperthyroidism respectively. Postpartum haemorrhage, pre term delivery, abortion and neonatal deaths were more common in females with thyroid dysfunction as compared to euthyroid females although not statistically significant.

Conclusions: Though pregnancy outcome was not found to be significantly adverse among females with thyroid dysfunction, very high prevalence of thyroid dysfunction among pregnant warrants its detection during antenatal care to be uniformly included in peripheral health care centres.


Keywords


Thyroid, Dysfunction, Pregnancy, Maternal outcome, Neonatal outcome

Full Text:

PDF

References


Tiwari D, Ruchika R, Anchal A, Bharti R, Sharma M. Prevalence of overt and subclinical hypothyroidism among indian pregnant women and its effect on foetomaternal outcome. J Evol Med Dent Sci. 2016;5(51):3342-7.

Hypothyroidism during pregnancy. Available at: https://nhm.gov.in/images/pdf/programmes/maternalhealth/guidelines/National_Guidelines_for_Screening_of_Hypothyroidism_during_Pregnancy.pdf. Accessed on 20 October 2022.

Shlomo M, Ronald K, Clifford R, Richard A, Allison G. Textbook of endocrinology. USA: Elsevier Health Sciences; 2018:2772.

Ajmani S, Aggarwal D, Bhatia P, Sharma M, Sarabhai V, Paul M. Prevalence of overt and subclinical thyroid dysfunction among pregnant women and its effect on maternal and fetal outcome. J Obstet Gynecol India. 2013;64(2):105-10.

Dhanwal DK, Bajaj S, Rajput R, Subramaniam K, Chowdhury S, Bhandari R, et al. Prevalence of hypothyroidism in pregnancy: An epidemiological study from 11 cities in 9 states of India. Indian J Endocr Metab. 2016;20:387-90.

Rajput R, Goel V, Nanda S, Rajput M, Seth S. Prevalence of thyroid dysfunction among women during the first trimester of pregnancy at a tertiary care hospital in Haryana. Indian J Endocrinol Metab. 2015;19(3):416.

Sahu MT, Das V, Mittal S, Agarwal A, Sahu M. Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome. Arch Gynecol Obstet. 2010;281:215-20

Vaidya B, Anthony S, Bilous M, Shields B, Drury J, Hutchison S, et al. Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding?. The J Clin Endocrinol Amp Metab. 2007;92(1):203-7.

Kaundinya A, Nagarsenkar A. Study of prevalence of thyroid disorders in pregnancy in a tertiary care hospital and its maternal and fetal outcome. J Dent Med Sci. 2016;15(12):41-6.

Nambiar V, Jagtap V, Sarathi V, Lila A, Kamalanathan S, Bandgar T, et al. Prevalence and Impact of Thyroid Disorders on Maternal Outcome in Asian-Indian Pregnant Women. J Thyroid Res. 2011;2011:1-6.

Saraladev R, Nirmala KT, Shreen B, Usha Rani V. Prevalence of thyroid disorder in pregnancy and pregnancy outcome. IAIM. 2016;3(3):1-11.

Pahwa S, Mangat S. Prevalence of thyroid disorders in pregnancy. Int J Reprod Contracept Obstet Gynecol. 2018;7:3493-6.

Krishnamma B. Prevalence of thyroid dysfunction in pregnant women and the need for universal screening: an observational study in Northern Andhra Pradesh population. Int J Reprod Contracept Obstet Gynecol. 2017;6(6):2536-40.