Characteristics of neonatal sepsis at a tertiary care centre in Western Uttar Pradesh, India: a hospital based retrospective study

Authors

  • Divyata Sachan Department of Community Medicine, SMMH Medical College, Saharanpur, Uttar Pradesh, India http://orcid.org/0000-0001-9089-9635
  • Pradip Kharya Department of Community Medicine, AIIMS, Gorakhpur, Uttar Pradesh, India
  • Prashant K. Bajpai Department of Community Medicine, KGMC, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2394-6040.ijcmph20222900

Keywords:

Neonatal sepsis, Early onset neonatal sepsis, Late onset neonatal sepsis, Antibiotic susceptibility, Antimicrobial sensitivity

Abstract

Background: Due to the constantly changing genome of the organisms causing disease it is important to be updated regarding the pattern of distribution of microbes and their antibiotic susceptibility. The study was conducted with the aim to determine the risk factors, microbial profile, antimicrobial susceptibility and the outcome of neonates diagnosed with neonatal sepsis.

Methods: A retrospective study was done using the data collected from medical records department of a tertiary care hospital. All the neonates diagnosed with clinical sepsis between 1to 31 January, 2019 were included in the present study. The data were analyzed using SPSS software version 24, IBM, corp., Chicago, U.S.A. Association between the outcome and independent variable were assessed using Chi square or Fischer exact test, while the level of association was assessed by univariate and multivariate analysis.

Results: During the study period, 332 neonates were registered in the hospital out of which 89 were diagnosed with clinical sepsis. Most of the neonates (64.9%) presented with early onset sepsis and were term neonates (68.5%) with birth weight less than 2.5 kg (53.4%). Parameters like mode of delivery (OR:6.18; CI:1.30-29.32), birth weight (OR:9.14; CI:2.38-35.10) and gestational age (OR:7.33; CI:2.32-23.12) were statistically associated with neonatal outcome. All gram-positive organisms were sensitive to vancomycin and linezolid. Gram negative organisms were resistant to cephalosporins, amoxicillin- clavulanic acid and piperacillin-tazobactam.

Conclusions: A high antibiotic resistance was observed among the isolated organism. The Gram positive and gram negative organisms were equally responsible for neonatal sepsis.

References

Singer M, Deutschman CS, Seymour CW. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801-10.

Liu L, Oza S, Hogan D. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385(9966):430-40.

Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Resp Med. 2018;6(3):223-30.

Bangi V, Devi S. Neonatal sepsis: A risk approach. J Dr NTR Uni Health Sci. 2014;3(4):254-58.

Kartik R. Evaluation of screening of neonatal sepsis. Int J Contemp Pediatr. 2006;5(2):580-3.

Edwards MS, Baker CJ. Krugman's infectious diseases of children. Sepsis in the Newborn. Philadelphia: Mosby; 2004: 545-561.

Murthy S, Godinho MA, Guddattu V, Lewis LE, Nair NS. Risk factors of neonatal sepsis in India: A systematic review and meta-analysis. PloS One. 2019;14(4):42-6.

Chaurasia S, Sivanandan S, Agarwal R, Ellis S, Sharland M, Sankar MJ. Neonatal sepsis in South Asia: huge burden and spiralling antimicrobial resistance. BMJ. 2019;364:k5314.

Viswanathan R, Singh AK, Mukherjee S, Mukherjee R, Das P, Basu S. Aetiology and antimicrobial resistance of neonatal sepsis at a tertiary care centre in eastern India: a 3 year study. Indian J Pediatr. 2011;78(4):409-12.

Agarwal R, Sankar J. Characterisation and antimicrobial resistance of sepsis pathogens in neonates born in tertiary care centres in Delhi, India: a cohort study. Lancet Global Health. 2016;4(10):e752-60.

Shrestha S, Shrestha NC, Singh SD. Bacterial isolates and its antibiotic susceptibility pattern in NICU. Kathmandu Uni Med J. 2013;11(1):66-70.

Marwah P, Chawla D, Chander J, Guglani V, Marwah A. Bacteriological profile of neonatal sepsis in a tertiary-care hospital of Northern India. Indian Pediatr. 2015;52(2):158-9.

Li G, Bielicki JA, Ahmed AN. Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: insights from the NeoAMR network. Arch Dis Childhood. 2020;105(1):26-31.

Downloads

Published

2022-10-29

How to Cite

Sachan, D., Kharya, P., & Bajpai, P. K. (2022). Characteristics of neonatal sepsis at a tertiary care centre in Western Uttar Pradesh, India: a hospital based retrospective study. International Journal Of Community Medicine And Public Health, 9(11), 4086–4090. https://doi.org/10.18203/2394-6040.ijcmph20222900

Issue

Section

Original Research Articles