DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20181969

Clinical, laboratory and radiological profile of dengue among pediatric patients admitted in tertiary care hospital

Sangeetha Jairaj, Sridhar D., Mettu Pradeep Reddy

Abstract


Background: Dengue is found in tropical and subtropical regions around the world, predominantly in urban and semi-urban areas. Dengue mortality can be reduced by implementing early case detection and referral systems for patients; managing severe cases with appropriate treatment; reorienting health services to cope with dengue outbreaks; and training health personnel at all levels of the health system. Many studies that focus on the difference between the frequency of clinical findings in DHF and dengue shock syndrome (DSS) with respect to classical DF has been published. The objectives of the study were to assess signs and symptoms of dengue among patients with severe dengue and patients with dengue fever and to evaluate laboratory and radiological profile among dengue patients.

Methods: This Hospital based cross sectional study was conducted on 70 seropositive cases, admitted in the Paediatrics Department of Gandhi hospital during the period of July to December 2017 for 6months. Data was analyzed by using SPPS Version 17 and student t test was used for inferential statistics.

Results: Out of 70 cases 38 were presented with severe dengue and 32 presented with dengue fever. Average age of presentation is 7.24 years among severe dengue group, 5.52 years among dengue fever group. In group of severe dengue, 60.5% of the cases were female, which was insignificantly more as compared to 40.6% of the cases from group of dengue fever.

Conclusions: All levels of health personnel must be aware of clinical signs and symptoms of all dengue types. Careful monitoring of unusual presentations early recognition severe manifestation and timely intervention can reduce disease specific mortality rate.


Keywords


Dengue fever, Severe dengue, Clinical laboratory and profiles

Full Text:

PDF

References


Narayanan M, Aravind MA, Thilothammmal N, Prema R, Sargunam CSR, Ramamurty N. Dengue fever epidemic in Chennai – A study of clinical profile and outcome. Indian Pediatr. 2002;39:1027-33.

Special programme for research, training in tropical diseases, and World Health Organization, dengue: guidelines for diagnosis, treatment, prevention and control, World Health Organization, Geneva, Switzerland; 2009.

Alberta Health Public Health Notifiable Disease Management Guidelines. 2012.

World Health Organization, Regional Office for South-East Asia. Comprehensive Guidelines for Prevention and Control of Dengue and Dengue Hemorrhagic Fever, Revised and Expanded Edition. WHO-SEARO 2011. (SEARO Technical Publication Series No. 60); 2011.

Ahmed FU, Mahmood BC, Sharma JD, Hoque SM, Zaman R, Hasan MS. Dengue and dengue haemorrhagic fever in children during the 2000 outbreak in Chittagong, Bangladesh. Dengue Bulletin. 2001;25:33-9.

Ahmed S, Arif F, Yahya Y, Rehman A, Abbas K, Ashraf S, et al. Dengue fever outbreak in Karachi 2006: a study of profile and outcome of children under 15 years of age. J Pakistan Med Assoc. 2008;58(1):4-8.

Mishra S, Ramanathan R, Agarwalla SK. Clinical profile of dengue fever in children: a study from Southern Odisha, India. Scientifica. 2016;6391594:6.

Rahman M, Rahman K, Siddque AK, Shoma S, Kamal AH, Ali KS, et al. First outbreak of dengue hemorrhagic fever, Bangladesh. Emerg Infect Dis. 2002;8:738-40.

Kobilan L, Balasubramanian S, Keshava SM. Dengue disease spectrum among infants in the 2001 dengue epidemic in Chennai, Tamilnadu, India. J Clin Microbiol. 2003;41:3919-21.

Mishra B, Itsstho RK. Virological interpretations of dengue disease spectrum in infants in Chennai, Tamil Nadu, India, need re-evaluation. J Clin Microbiol. 2004;42:23-7.

Harris E, Videa E, Perez L, Sandoval E, Tellez Y, Perez ML, et al. Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua. Am J Trop Med Hyg. 2000;63:5-11.

Murgue B, Deparis X, Chungue E, Cassar O, Roche C. Dengue: an evaluation of dengue severity in French Polynesia based on an analysis of 403 laboratory- confirmed cases. Trop Med Int Health. 1999;4:765-73.

Mittal HM, Faridi MA, Arora SK, Patil R, Clinicohematological profile and platelet trends in children with dengue during 2010 epidemic in North India. Indian J Pediatr. 2012;79(4):467-71.

Aggarwal A, Chandra J, Aneja S, Patwari AK, Dutta AK. An epidemic of dengue hemorrhagic fever and dengue shock syndrome in children in Delhi. Indian Pediatr. 1998;35:727-32.

Kalayanarooj S, Vaughn DW, Nimmannitya S. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis. 1997;176(2):313-21.

Pushpa V, Venkatadesikalu M, Mohan S, Cherian T, John TJ, Ponnuraj EM. An epidemic of dengue haemorrhagic fever/dengue shock syndrome in tropical India. Ann Trop Pediatr. 1998;18:289-93.

Malavige GN, Ranatunga PK, Velathanthiri VGNS, Fernando S, Karunatilaka DH, Aaskov J, et al. Patterns of disease in Sri Lankan dengue patients. Arch Dis Child. 2006;91:396-400.

Joshi R, Baid V. Profile of dengue patients admitted to a tertiary care hospital in Mumbai. Turkish J Pediatr. 2011;53(6):626-31.

Srivastava VK, Suri S, Bhasin A, Srivastava L, Bharadwaj M. An epidemic of dengue hemorrhagic fever and dengue shock syndrome in Delhi: a clinical study. Ann Trop Pediatr. 1990;10:329-34.