DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20181494

Prediabetes and serum insulin levels

Alwaleed Altemani, Ali Alamri, Mahir Ahmed, Mosaed Al Garbo, Tariq Alharbi, Rana Al-Rasheed, Saud Alshagraawi, Ibrahim Alzilai, Fuad Alotaibi, Ahlam Al-shahrani

Abstract


Prediabetes remains a diagnostic dilemma. It refers to impaired glycaemic values without reaching the threshold for diagnosing diabetes mellitus. Prediabetes is an important risk factor for the development of diabetes mellitus, and it constitutes the stage during which microvascular and macrovascular complications are initiated. Early and accurate identification of this stage is the gold standard for prevention of diabetes and its consequences. Despite the multiplicity of diagnostic tests proposed for identification of this condition, a reliable test remains elusive. This article aims at reviewing the different available tests for diagnosis of prediabetes states with a focus on serum insulin levels. Insulin plays a major role in the pathophysiology and development of prediabetes. Different mechanisms of insulin resistance and insulin secretion are established in different subtypes of prediabetes. Therefore, fasting insulin level seems to be a reliable and promising tool for diagnosis and management of prediabetes.  


Keywords


Prediabetes, Insulin level

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References


Goldenberg R, Punthakee Z. Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome. Can J Diabetes. 2013;37(1):8-11.

Vas PRJ, Alberti KG, Edmonds ME. Prediabetes: moving away from a glucocentric definition. Lancet Diabetes Endocrinol. 2017;5(11):848-9.

Færch K, Witte DR, Brunner EJ, Kivimäki M, Tabák A, Jørgensen ME, et al. Physical Activity and Improvement of Glycemia in Prediabetes by Different Diagnostic Criteria. The Journal of clinical endocrinology and metabolism. 2017;102(10):3712-21.

Tabák AG, Herder C, Rathmann W, Brunner EJ, Kivimäki M. Prediabetes: A high-risk state for diabetes development. Lancet. 2012;379(9833):2279-90.

Souza CF, Gross JL, Gerchman F, Leitao CB. Prediabetes: diagnosis, evaluation of chronic complications, and treatment. Arq Bras Endocrinol Metab. 2012;56(5):275-84.

Bansal N. Prediabetes diagnosis and treatment: A review. World J Diabetes. 2015;6(2):296.

Watson CS. Prediabetes: Screening, Diagnosis, and Intervention. J Nurse Pract. 2017;13(3):216-221.e1.

Abraham TM, Fox CS. Implications of rising prediabetes prevalence. Diabetes Care. 2013;36(8):2139-41.

Yip WCY, Sequeira IR, Plank LD, Poppitt SD. Prevalence of pre-diabetes across ethnicities: A review of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) for classification of dysglycaemia. Nutrients. 2017;9(11):1273.

Centers for Disease Control and Prevention. National Diabetes Statistics Report; 2017; 2017.

Díaz-Redondo A, Giráldez-García C, Carrillo L, Serrano R, García-Soidán FJ, Artola S, et al. Modifiable risk factors associated with prediabetes in men and women: A cross-sectional analysis of the cohort study in primary health care on the evolution of patients with prediabetes. BMC Fam Pract. 2015;16(1):5.

Kawada T. Risk factors for developing prediabetes. Diabetes Res Clin Pract. 2018;135:232.

American Diabetes Association. 2016 American Diabetes Association (ADA) Diabetes Guidelines Summary Recommendation from NDEI. Natl Diabetes Educ Initiat. 2016;39(1):1-46.

Retnakaran R, Qi Y, Sermer M, Connelly PW, Zinman B, Hanley AJG. Comparison of National Diabetes Data Group and American Diabetes Association diagnostic criteria for gestational diabetes in their identification of postpartum risk of glucose intolerance. Diabetes Res Clin Pract. 2009;85(1):40-6.

Seino Y, Nanjo K, Tajim N, Kadowaki T, Kashiwagi A, Araki E, et al. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig. 2010;1(5):212-28.

Rhee SY, Woo JT. The prediabetic period: Review of clinical aspects. Diabetes Metab J. 2011;35(2):107-16.

The ARIC Investigators. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol. 1989;129(4):687-702.

Kilpatrick ES, Bloomgarden ZT, Zimmet PZ. Is haemoglobin A1c a step forward for diagnosing diabetes? BMJ. 2009;339:4432.

Olson DE, Rhee MK, Herrick K, Ziemer DC, Twombly JG, Phillips LS. Screening for diabetes and pre-diabetes with proposed A1C-based diagnostic criteria. Diabetes Care. 2010;33(10):2184-9.

Unwin N, Shaw J, Zimmet P, Alberti KGMM. Impaired glucose tolerance and impaired fasting glycaemia: The current status on definition and intervention. Diabetic Medicine. 2002;19:708-23.

Lebovitz HE. Insulin resistance: Definition and consequences. Exp Clin Endocrinol Diabetes. 2001;109(2).

Ferrannini E, Gastaldelli A, Iozzo P. Pathophysiology of Prediabetes. Med Clin North Am. 2011;95(2):327-39.

Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: Results from the veterans administration genetic epidemiology study. Diabetes. 2006;55(5):1430-5.

Bock G, Man CD, Campioni M, Chittilapilly E, Basu R, Toffolo G, et al. Pathogenesis of pre-diabetes: Mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and/or impaired glucose tolerance. Diabetes. 2006;55(12):3536-49.

Færch K, Vaag A, Holst JJ, Glümer C, Pedersen O, Borch-Johnsen K. Impaired fasting glycaemia vs impaired glucose tolerance: Similar impairment of pancreatic alpha and beta cell function but differential roles of incretin hormones and insulin action. Diabetologia. 2008;51(5):853-61.

Kærch K, Vaag A, Holst JJ, Hansen T, Jøhnsen T, Borch-Johnsen K. Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: The inter99 study. Diabetes Care. 2009;32(3):439-44.

Rhee SY, Kim JY, Chon S, Hwang YC, Jeong IK, Oh S, et al. The changes in early phase insulin secretion in newly diagnosed, drug naive korean prediabetes subjects. Korean Diabetes J. 2010;34(3):157-65.

Tuomilehto J, Indstrom J, Eriksson J, Valle T, HE& UM. Prevention of Type 2 Diabetes Mellitus By Changes in Lifestyle Among Subjects With Impaired Glucose Tolerance. N Engl J Med. 2001;344(18):1343-50.

Papaetis GS. Incretin-based therapies in prediabetes: Current evidence and future perspectives. World J Diabetes. 2014;5(6):817.

Prasad-Reddy L, Isaacs D. A clinical review of GLP-1 receptor agonists: Efficacy and safety in diabetes and beyond. Drugs Context. 2015;4.

Johnson J, Duick D, Chui M, Aldasouqi S. Identifying Prediabetes Using Fasting Insulin Levels. Endocr Pract. 2010;16(1):47-52.

Cobb J, Gall W, Adam KP, Nakhle P, Button E, Hathorn J, et al. A novel fasting blood test for insulin resistance and prediabetes. J Diabetes Sci Technol. 2013;7(1):100-10.