DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20182176

Seroprevalence and trends of transfusion transmitted infections in blood donors of rural tertiary care hospital blood bank: a 3 year retrospective study in Chamba (HP)

Ishan Arora, Shairoly Singh, Shireen Singh

Abstract


Background: Timely transfusion of blood saves millions of lives, but unsafe transfusion practices puts millions of people at risk of transfusion transmissible infections (TTIs). Blood transfusion carries the risk of transfusion-transmissible infections including human immunodeficiency virus (HIVI&II), hepatitis B virus (HBV), hepatitis C virus (HCV), malaria and syphilis. With every unit of blood there are 1% chances of transfusion associated diseases.

Methods: This study was conducted over a period of 3 years (1stJanuary 2015-31st December 2017) at hospital blood bank of Pt. Jawaharlal Nehru Government Medical College, Chamba (H.P). The study was conducted on both voluntary and replacement blood donors who came to our blood bank and voluntary blood donation camps in and around Chamba. Statistical analysis used. Collected data was analyzed using appropriate statistical softwares such as EPI-INFO and MS-Excel.

Results: In our study, we observed a total of 2616 donors over a period of 3 years. In the present study, 847 (32.37%) were voluntary donors and 1769 (67.62%) were replacement donors. Out of 2616 blood samples, 8 were HBsAg positive, 1 HCV positive.

Conclusions: Our study shows that the number of blood donors is increasing every year. In our study, the seroprevalence of HBsAg was 0.3% and Hep C was 0.03% in total blood donors. The knowledge of current infectious disease pattern and trends in donor population can help in planning of future blood transfusion related health challenges. 


Keywords


Blood bank, Blood donors, Replacement donors, Voluntary donors, Transfusion transmitted infections

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References


Bihl F, Castelli D, Marincola F, Dodd RY, Brander C. Transfusion transmitted infections. J Trans Med. 2007;5:25.

Widmann FK, eds. Technical manual American association of blood banks. Aglinton USA, 1985: 325-344

Zaheer H, Saeed U, Waheed Y, Karimi S, Waheed U. Prevalence and trends of hepatitis B, hepatitis C and human immunodeficiency viruses among blood donors in Islamabad, Pakistan 2005-2013. J Blood Disorders Transf. 2014;5(217):2.

Walter SR, Thein HH, Amin J, Gidding HF, Ward K, Law MG, et al. Trends in mortality after diagnosis of hepatitis B or C infection: 1992-2006. J Hepatol. 2011;54(5):879-86.

World Health Organization. Available at: http://www.who.int/gpv-surv/graphics/htmls/ hepbprev.htm. Accessed on 16 November 2009.

Singh N. NAT: Safe Blood, Safe India. Available at: http://www.expresshealthcare.in/200810/knowledge02.shtml. Accessed on 9 December 2011.

Mujeeb SA, Kausar A, Khalid M. Seroprevalence of HBV, HCV, and HIV infection among college going voluntary donors. J Pak Med Assoc. 2000;50:269–70.

Kakkar N, Kaur R, Dhanoa J. Voluntary donors-need for a second look. Indian J Pathol Microbiol. 2004;47(3):381-3.

Singh B, Verma M, Kotru M, Verma K, Batra M. Prevalence of HIV and VDRL seropositivity in blood donors of Delhi. Indian J Med Res. 2005;122(3):234-6.

Srikrishna A, Sitalakshmi S, Damodar P. How safe are our safe donors? Indian J Pathol Microbiol. 1999;42(4):411-6.

Qureshi M, Bashir H, Maroof P, Jeelani S, Bhat N, Akhter F. Seropositivity of hepatitis b virus and hepatitis c virus among blood donors at a tertiary care hospital in Kashmir: a ten-year study. Int J Current Res Rev. 2016;8(19):17-20.

Patel PA, Patel SP, Oza H. Seroprevalence of transfusion transmitted infections (TTIs) in blood donors at western Ahmedabad–a secondary care hospital based study. Int J Biol Med Res. 2012;3(2):1806-10.

Gupta PK, Kumar H, Basannar DR, Jaiprakash M. Transfusion transmitted in infections in armed forces: prevalence and trends. MJAFI. 2006;62:348–50.

Ahmed Z, Umaru N, Shreesha K. Seroprevalence of Transfusion Transmitted Infections Among Blood Donors In Mangalore. Medica Innovatica. 2012;1(2):24-27.

Pallavi P, Ganesh CK, Jayashree K, Manjunath GV. Seroprevalence and trends in Transfusion Transmitted Infections Among Blood Donors in a University Hospital Blood Bank: A 5 year study. Indian J Hematol Blood Transfus. 2011;27(1):1-6.

Adhikari L, Bhatta D, Tsering DC, Sharma DK, Pal R, Gupta A. Infectious disease markers in blood donors at Central Referral Hospital, Gangtok, Sikkim. Asian J Transfus Sci. 2010;4:41–2.

Arora D, Arora B, Khetarpal A. Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana. Indian J Pathol Microbiol. 2010;53:308–9. .

Bhattacharya P, Chandra PK, Datta S, Banerjee A, Chakraborty S, Rajendran K, et al. Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection. World J Gastroenterol. 2007;13:3730–3.

Garg S, Mathur DR, Garg DK. Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indian J Pathol Microbiol. 2001;44:409–12.

Panda M, Kar K. HIV, hepatitis B and C infection status of the blood donors in a blood bank of a tertiary health care centre of Orissa. Indian J Public Health. 2008;52:43–4.

Giri PA, Deshpande JD, Phalke DB, Karle LB. Seroprevalence of Transfusion Transmissible Infections Among Voluntary Blood Donors at a Tertiary Care Teaching Hospital in Rural Area of India. J Family Med Prim Care. 2012;1(1):48–51.

Chandra T, Kumar A, Gupta A. Prevalence of transfusion transmitted infections in blood donors: an Indian experience. Trop Doct. 2009;39:152–4.

Patel PJ. Transfusion transmissible infections in blood donors: A 7-year study in central Gujarat. Med J DY Patil Univ. 2014;7:620-4

Chandekar A, Amonkar G, Desai H, Valvi N, Puranik G. Seroprevalence of transfusion transmitted infections in healthy blood donors: A 5-year Tertiary Care Hospital experience. J Lab Physicians. 2017;9(4):283–7.

Kumar A, Sharma S, Ingole N, Gangane N. Rising trends of HCV infection over a period of 4 years among blood donors in central India: A retrospective study. Int J Med Public Health. 2013;3:240-3.